衰老机制与干预研究进展  

Research status and prospect of aging mechanism and intervention

作　　者：李静宜 范艳玲 黄皓琰 张译元 刘蓓蓓 刘光慧 LI Jingyi;FAN Yanling;HUANG Haoyan;ZHANG Yiyuan;LIU Beibei;LIU Guanghui(Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;Beijing Institute of Genomics,Chinese Academy of Sciences and China National Center for Bioinformation,Beijing 100101,China;Xuanwu Hospital Capital Medical University,Beijing 100053,China;Beijing institute for Stem Cell and Regenerative Medicine Beijing,Beijing 100101,China)

机构地区：[1]中国科学院动物研究所,北京100101 [2]中国科学院北京基因组研究所(国家生物信息中心),北京100101 [3]首都医科大学宣武医院,北京100053 [4]北京干细胞与再生医学创新研究院,北京100101

出　　处：《科技导报》2024年第22期6-14,共9页Science & Technology Review

摘　　要：衰老是机体伴随时间推移而出现的一系列器官功能衰退的过程,与多种慢性疾病的发生密切相关。揭示衰老的生物学基础并制定有效的干预措施,已成为生物医学界面临的一项重要且紧迫的课题。探讨了衰老研究的核心问题,从衰老模型构建、机制探索、程度评估及干预策略实施等层面综述了相关进展。分析表明,衰老研究需要构建多元化、系统性的研究体系,采用还原论与整体观相结合的思维解析衰老机制,开发具有普适性、可靠性和高灵敏性的检测体系,以及发展精准高效的衰老干预策略,以全面应对衰老带来的挑战。The progressive intensification of the population aging trend has rendered proactive engagement with this challenge exceedingly imperative.Aging denotes the organ function decline over time,the process of which is closely related to the occurrence of a variety of chronic diseases.To reveal the biological basis of aging and develop effective intervention measures has become an important and urgent issue facing the biomedical community.In this paper,the core issues of aging research were discussed,and the construction of aging model,mechanism exploration,quantification of aging degrees and implementation of intervention strategies were reviewed.The following suggestions are made:a diversified and systematic research system should be adopted in the research of aging;the aging mechanism is interpreted through the thinking combining reductionism and holistic view;a universal,reliable and highly sensitive detection system should be explored,and accurate and efficient aging intervention strategies should be developed to address the challenges posed by population aging.

关 键 词：衰老机制 干预策略 人口老龄化 生物医学研究 

分 类 号：R339.38[医药卫生—人体生理学]