大豆与花生过敏原组分诊断解读:主要组分识别及临床管理策略  

Diagnosis of soybean and peanut allergen components:identification of major components and clinical management strategies

作　　者：陈莹莹[1] 罗文婷[1] 张嘉乐 孙宝清[1] Chen Yingying;Luo Wenting;Zhang Jiale;Sun Baoqing(Department of Clinical Laboratory of the First Affiliated Hospital of Guangzhou Medical University,State Key Laboratory of Respiratory Disease,National Center for Respiratory Medicine,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,Guangzhou510120,China)

机构地区：[1]广州医科大学附属第一医院临床检验中心,呼吸疾病全国重点实验室,国家呼吸医学中心,国家呼吸系统疾病临床研究中心,广州呼吸健康研究院,广州510120

出　　处：《中华预防医学杂志》2024年第12期2057-2064,共8页Chinese Journal of Preventive Medicine

基　　金：广州市科创委市校(院)联合基金(2023A03J0365);广东省钟南山医学基金会(20220081,20240015);呼吸疾病全国重点实验室临床及流行病学研究专项课题资助(SKLRD-L-202505);广州医科大学多中心临床研究课题资助(GMUCR2024-01009)。

摘　　要：大豆、花生均属于豆科植物,是食物过敏性反应的常见诱因。过敏症状从口腔过敏综合征,到严重的呼吸困难、过敏性休克甚至死亡。同属豆科植物过敏患者,由于引起过敏的过敏原不同,其症状严重程度也不同,在此种情况下,基于分子水平的精准诊断或过敏原组分诊断(component-resolved diagnosis,CRD)是很有必要的。CRD是一种精准识别过敏原蛋白的技术,帮助医生为过敏患者提供个性化的脱敏治疗和管理策略。本文根据欧洲过敏和临床免疫学会(European Academy of Allergy and Clinical Immunology,EAACI)发布的《过敏原组分诊断指导建议2.0》(MAUG 2.0)解读了大豆和花生过敏原主要致敏组分识别、临床诊断、治疗及管理,旨在提高大豆和花生过敏的精准诊断和个性化治疗水平。Soybeans and peanuts belong to the leguminous family and are common causes of food anaphylaxis.Symptoms range from oral allergy syndrome to severe breathing difficulties,anaphylactic shock,and even death.But the allergens causing allergies are different,and the severity of symptoms are different.Precise diagnosis at the molecular level or component-resolved diagnosis(CRD)is necessary.CRD is a technology that accurately identifies allergen proteins to help physicians personalize clinical treatment and management strategies for allergy patients.In this article,according to the European Academy of Allergy and Clinical Immunology(EAACI)issued the"Allergen Component Diagnostic Guidance Recommendation 2.0(MAUG 2.0)",it introduces the soy and peanut allergenic components,clinical diagnosis,treatment and management,aimed at improving the accurate diagnosis and personalized treatment of soy and peanut allergy.

关 键 词：大豆 花生 过敏反应 过敏原组分诊断 精准诊断 

分 类 号：R593.1[医药卫生—内科学]