婴幼儿呼吸道合胞病毒毛细支气管炎病情程度的影响因素分析  

Analysis of factors influencing the condition of respiratory syncytial virus capillary bronchiolitis in infants and young children

作　　者：庞大艳 陈学高[1] PANG Dayan;CHEN Xuegao(Pediatric Department of Linquan County People's Hospital,Fuyang,Anhui 236400,China)

机构地区：[1]临泉县人民医院儿科,安徽阜阳236400

出　　处：《中国国境卫生检疫杂志》2024年第6期604-608,共5页Chinese Journal of Frontier Health and Quarantine

基　　金：安徽省自然科学基金项目(1908085MH273)。

摘　　要：目的分析婴幼儿呼吸道合胞病毒(RSV)毛细支气管炎病情程度的相关影响因素,为临床防治提供依据。方法选取2020年2月—2023年5月临泉县人民医院收治的78例RSV毛细支气管炎患儿纳入观察组,依据病情分为轻度组(32例)、中度组(28例)及重度组(18例),选取同期体检的65名健康婴幼儿纳入对照组。比较观察组、对照组的一般资料,比较不同病情患儿的成骨细胞特异因子(POSTN)、嗜酸粒细胞阳离子蛋白(ECP)、25-羟基维生素D3[25(OH)D_(3)]、白介素10(IL-10)、高迁移率族蛋白B1(HMGB1)、白三烯C4合成酶(LTC4S)A-444C基因型和等位基因分布。结果两组婴幼儿的性别、年龄、BMI、是否早产、出生体重差异无统计学意义(P>0.05),观察组人工喂养方式比例(35.90%)、POSTN(498.63±32.66)、ECP(18.54±5.67)、IL-10(13.05±5.24)、HMGB1(0.41±0.05)高于对照组(P<0.05),观察组25(OH)D_(3)(47.55±7.33)低于对照组(P<0.05);三组患儿的POSTN、ECP、IL-10、HMGB1从低到高依次是轻度组<中度组<重度组(P<0.05),而25(OH)D_(3)从低到高依次是重度组(43.24±7.02)<中度组(52.47±6.63)<轻度组(70.24±5.36)(P<0.05)。轻度组患儿AA基因型比例(53.13%)低于中度组(85.71%)、重度组(100.00%)(P<0.05),而中度组和重度组差异无统计学意义(P>0.05),轻度组A等位基因分布(70.31%)低于中度组(89.29%)、重度组(97.22%)(P<0.05),而中度组和重度组差异无统计学意义(P>0.05)。Logistic回归分析发现人工喂养、POSTN、ECP、25(OH)D_(3)、IL-10、HMGB1、AA基因型及A等位基因分布是RSV毛细支气管炎患儿病情加重的影响因素(P<0.05)。结论人工喂养、POSTN、ECP、25(OH)D_(3)、IL-10、HMGB1、AA基因型及A等位基因分布与RSV毛细支气管炎患儿病情严重程度有关。Objective To analyze the influencing factors related to the condition of respiratory syncytial virus(RSV)capillary bronchiolitis in infants and young children,and to provide a basis for clinical prevention and treatment.Methods Seventy-eight cases of RSV capillary bronchiolitis admitted to Linquan County People's Hospital from February 2020 to May 2023 were selected to be included in the observation group,which was divided into mild(32 cases),moderate(28 cases)and severe group(18 cases)according to their conditions,and 65 healthy infants and young children who had a physical examination during the same period were selected to be included in the control group.The general data of the two groups were compared.Periostin(POSTN),eosinophil cationic protein(ECP),25-hydroxyvitamin D33[25(OH)D],interleukin 10(IL-10),high mobility group protein B1(HMGB1),leukotriene C4 synthase(LTC4S)A-444C genotype and allele distribution of the children in the different groups were compared.Results There was no statistically significant difference in gender,age,BMI,whether preterm birth,and birth weight between the two groups(P>0.05).The proportion of artificial feeding mode(35.90%),POSTN(498.63±32.66),ECP(18.54±5.67),IL-10(13.05±5.24)and HMCB1(0.41±0.05)in the observation group was higher than the control group(P<0.05),and 25(OH)D,(47.55±7.33)was lower than the control group(P<0.05).POSTN,ECP,IL-10 and HMCB1 of the three groups were in the order of mild group<moderate group<severe group(P<0.05)from low to high,while 25(OH)D_(3) was in the order of severe group(43.27±7.02)<moderate group(52.47±6.63)<mild group(70.24±5.36)(P<0.05).The proportion of AA genotype in the mild group(53.13%)was lower than that in the moderate group(85.71%)and severe group(100.00%)(P<0.05),while the difference between the moderate group and the severe group was not statistically significant(P>0.05).The distribution of A allele in the mild group(70.31%)was lower than that in the moderate group(89.29%)and severe group(97.22%)(P<0.05),while the difference b

关 键 词：呼吸道合胞病毒 毛细支气管炎 成骨细胞特异因子 嗜酸粒细胞阳离子蛋白 25-羟基维生素D3 白介素10 高迁移率族蛋白B1 

分 类 号：R183.3[医药卫生—流行病学] R725.6[医药卫生—公共卫生与预防医学]