呼吸道合胞病毒合并细菌感染致喘息性支气管肺炎半乳糖凝集素表达及意义  

Expression and significance of Galectin in asthmatic bronchopneumonia induced by respiratory syncytial virus combined with bacterial infection

作　　者：司凡 肖寺平 魏华 SI Fan;XIAO Siping;WEI Hua(Department of Respiratory Medicine,Langxi People's Hospital,Xuancheng,Anhui 242100,China)

机构地区：[1]郎溪县人民医院呼吸科,安徽宣城242100

出　　处：《中国国境卫生检疫杂志》2024年第6期612-614,635,共4页Chinese Journal of Frontier Health and Quarantine

基　　金：安徽省重点研究与开发计划项目(1804h08020236)。

摘　　要：目的分析呼吸道合胞病毒合并细菌感染致喘息性支气管肺炎半乳糖凝集素(Galectin)-1、Galectin-9表达水平,为临床研究提供参考。方法2020年1月—2023年10月郎溪县人民医院收治的1174例喘息性支气管肺炎患者,经免疫荧光法检测确认感染呼吸道合胞病毒、细菌,用xMark全自动酶标仪检测血清T细胞免疫球蛋白黏蛋白分子3(TIM-3)、Galectin-1、Galectin-9水平。将患者分为有效组和无效组,分析Galectin-1、Galectin-9水平预测呼吸道合胞病毒合并细菌感染致喘息性支气管肺炎患者疗效的影响因素。结果无效组患者的TIM-3(8.19±1.28)ng/ml、Galectin-1(15.74±2.86)ng/ml、Galectin-9(35.78±4.18)ng/ml,均高于有效组。经二元Logistic回归分析,TIM-3、Galectin-1、Galectin-9是影响喘息性支气管肺炎患者治疗无效的危险因素(P<0.05),ROC曲线分析显示Galectin-1、Galectin-9及二者联合检测的灵敏度分别为80.95%、80.95%、90.48%,特异度分别为83.33%、84.38%、94.79%,且二者联合预测患者记录无效均高于单一预测(AUC>0.09)。结论早期Galectin-1、Galectin-9联合检测对呼吸道合胞病毒合并细菌感染致喘息性支气管肺炎患者疗效有较好预测价值。Objective To analyze the expression levels of Galectin-1 and Galectin-9 in asthmatic bronchopneumonia induced by respiratory syncytial virus(RSV)and bacterial infection,to provide reference for clinical study.Methods A total of 1174 patients with asthmatic bronchopneumonia admitted to Langxi People's Hospital from January 2020to October 2023 were selected,RSV and bacterial infection were detected by immunofluorescence.Serum T cell im-munoglobulin mucin-3(TIM-3),Galectin-1 and Galectin-9 levels were detected by xMark automatic absorbance read-er.The patients were divided into effective group and ineffective group,the influencing factors of Galectin-1 and Galectin-9 levels in predicting the curative effect of RSV with bacteria infection induced asthmatic bronchopneumonia were analyzed.Results TIM-3[(8.19±1.28)ng/ml],Galectin-1[(15.74±2.86)ng/ml]and Galectin-9[(35.78±4.18)ng/ml]in the ineffective group were higher than those in the effective group.By binary Logistic regression analysis,TIM-3,Galectin-1 and Galectin-9 were the risk factors for treatment failure in patients with asthmatic bronchopneumonia(P<0.05).ROC curve analysis showed that the sensitivity of Galectin-1,Galectin-9 and combined detection were 80.95%,80.95%and 90.48%,respectively.The specificity was 83.33%,84.38%and 94.79%,respectively.The combined prediction was higher than that of single prediction(AUC>0.09).Conclusion The combined detection of Galectin-1and Galectin-9 in early stage had a good predictive value for RSV patients with asthmatic bronchopneumonia caused by bacteria infection.

关 键 词：呼吸道合胞病毒 细菌感染 喘息性支气管肺炎 半乳糖凝集素 

分 类 号：R183.3[医药卫生—流行病学] R563.12[医药卫生—公共卫生与预防医学]