pks+肺炎克雷伯菌流行病学及其与结直肠癌的相关性研究进展  

Epidemiology of pks+Klebsiella pneumoniae and its association with colorectal cancer:research progress

作　　者：张丽 王群 张晓煜 林勇平 ZHANG Li;WANG Qun;ZHANG Xiaoyu;LIN Yongping(Department of Laboratory Medicine,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen,Guangdong 518116,China)

机构地区：[1]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院检验科,广东深圳518116

出　　处：《中国国境卫生检疫杂志》2024年第6期648-651,共4页Chinese Journal of Frontier Health and Quarantine

基　　金：深圳市医疗卫生三名工程项目(SZSM202311002)。

摘　　要：肺炎克雷伯菌(Klebsiella pneumoniae)是一种革兰阴性杆菌,常导致医院获得性感染。近年来,其通过携带pks基因的新致病特性引起了科学界的广泛关注,特别是其与结直肠癌的潜在关联。pks基因岛赋予菌株合成特定多聚酮化合物如colibactin的能力,这些化合物具有细胞毒性和基因毒性,并能够与宿主细胞DNA结合,导致DNA损伤,可能促进癌症的发生。流行病学研究显示,pks+肺炎克雷伯菌的感染率逐年上升,广泛分布于全球多个地区。鉴于其与结直肠癌之间的潜在关系,本文综述了pks+肺炎克雷伯菌的流行病学特征及其与结直肠癌的相关研究进展,为未来的研究和临床管理提供借鉴。Klebsiella pneumoniae is a Gram negative bacillus frequently responsible for hospital acquired infections.In recent years,its new pathogenic traits,attributed to the presence of the pks gene cluster,have garnered significant attention from the scientific community,particularly regarding its potential link to colorectal cancer.The pks gene island endows the strains with the ability to synthesize specific polyketide compounds,such as colibactin,which possess cytotoxic and genotoxic properties.These compounds can bind to host cell DNA,causing DNA damage,and possibly facilitating cancer development.Epidemiological studies indicate that the infection rate of pks+Klebsiella pneumoniae is rising annually and is widely distributed globally.Given its potential association with colorectal cancer,this article reviewed the epidemiological characteristics of pks+Klebsiella pneumoniae and its related research progress concerning colorectal cancer,aimed to provide insights for future research and clinical management.

关 键 词：聚酮合酶 肺炎克雷伯菌 毒力基因 结直肠癌 流行病学 微生物组 

分 类 号：R183[医药卫生—流行病学] R378[医药卫生—公共卫生与预防医学]