内皮细胞来源的外泌体及其调控的线粒体功能变化在心血管疾病中的研究进展  

Research progress on endothelial exosomes and mitochondrial dysfunction in cardiovascular diseases

作　　者：唐婷 路旭阳 焦凯 马雅楠 刘德敏[1] Tang Ting;Lu Xuyang;Jiao Kai;Ma Yanan;Liu Demin(Department of Cardiology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院心内一科,石家庄050000

出　　处：《中国心血管杂志》2024年第6期579-584,共6页Chinese Journal of Cardiovascular Medicine

基　　金：国家自然科学基金(82100301);河北省自然科学基金精准医学联合基金培育项目(H2021206220);河北省自然科学基金精准医学联合重点项目(H2020206409);河北省医学科学重点科技研究计划(20220989)。

摘　　要：心血管疾病是导致人类死亡的主要原因之一。内皮细胞释放的外泌体通过信号传导传递其携带的生物分子,从而影响心血管疾病进程。线粒体作为细胞动力源,当其出现功能障碍时会导致多种心血管疾病的发生。本文主要从内皮细胞来源的外泌体对心血管疾病的影响,以及其调控的线粒体功能变化在心血管疾病模型中所发挥的作用等方面进行综述。Cardiovascular disease is one of the leading causes of death in humans.The exosomes released by endothelial cells transmit the biomolecules and influence the course of cardiovascular disease through signal transduction.Mitochondria as the power source of cells,when dysfunction,will lead to ATP production disorders and a variety of cardiovascular diseases.This article reviews the recent progress of exosomes and mitochondrial functions in cardiovascular diseases from the aspects of the effects of exosomes derived from endothelial cells on cardiovascular diseases and the role of mitochondrial functions regulated by exosomes in cardiovascular disease models.

关 键 词：心血管疾病 内皮细胞 外泌体 线粒体功能障碍 

分 类 号：R54[医药卫生—心血管疾病]