线粒体功能障碍与脓毒症心肌病的研究进展  

Research progress on mitochondrial dysfunction and septic cardiomyopathy

作　　者：于紫英[1] 刘峰涛[2] 曾勇智[2] Yu Ziying;Liu Fengtao;Zeng Yongzhi(Department of Emergency,the First Affiliated Hospital of University of South China,Hengyang 421001,China;Institute of Cardiovascular Disease,University of South China&Key Laboratory for Atherosclerology of Hunan Province,Hengyang 421001,China)

机构地区：[1]南华大学附属第一医院急诊科,衡阳421001 [2]南华大学心血管疾病研究所动脉硬化学湖南省重点实验室,衡阳421001

出　　处：《中国心血管杂志》2024年第6期593-596,共4页Chinese Journal of Cardiovascular Medicine

基　　金：湖南省自然科学基金(2021JJ40505、2021JJ30588);湖南省卫生健康委科研课题(202102062188)。

摘　　要：脓毒症是由宿主对感染的反应失调而引起的危及生命的器官功能障碍。脓毒症心肌病作为脓毒症最严重的并发症,其发生发展与心肌线粒体功能损伤密切相关。本文将就线粒体结构、线粒体质量控制体系、线粒体功能改变与脓毒症心肌病之间的联系进行综述,为脓毒症心肌病的诊断及治疗提供新的策略。Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to the infection.As the most severe complication of sepsis,the occurrence and development of sepsis-induced cardiomyopathy are closely related to the myocardial mitochondrial function injury.This article explores the relationships between mitochondrial structure,mitochondrial quality control system,mitochondrial function changes and septic cardiomyopathy,aiming to provide new strategies for diagnosis and treatment of septic cardiomyopathy.

关 键 词：脓毒症 线粒体 心脏 自噬 心肌病 

分 类 号：R542.2[医药卫生—心血管疾病] R459.7[医药卫生—内科学]