早发性精神分裂症患者脑灰质结构改变:一项基于体素的形态学测量的元分析  

Structural changes in gray matter of the brain in patients with early-onset schizophrenia:Ameta-analysis of voxel-based morphometry

作　　者：王露 刘芮杉 廖娟 夏林枫 卓丽华 李宏伟 WANG Lu;LIU Ruishan;LIAO Juan;XIA Linfeng;ZHUO Lihua;LI Hongwei(Department of Radiology,the Third Hospital of Mianyang,Sichuan Mental Health Center,Mianyang 621000,China;Medical Imaging College,North Sichuan Medical College,Nanchong 637000,China;Department of Neurosurgery,the Third Hospital of Mianyang,Sichuan Mental Health Center,Mianyang 621000,China)

机构地区：[1]绵阳市第三人民医院(四川省精神卫生中心)放射科,绵阳621000 [2]川北医学院医学影像学院,南充637000 [3]绵阳市第三人民医院(四川省精神卫生中心)神经外科,绵阳621000

出　　处：《磁共振成像》2024年第11期17-23,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家重点研发计划项目(编号:2022YFC2009901-05/2022YFC2009900);成都市科技计划项目(编号:2022-YF09-00062-SN)。

摘　　要：目的针对早发性精神分裂症(early-onset schizophrenia,EOS)脑灰质体积(gray matter volume,GMV)存在显著异常的脑区进行有效整合分析,以确定EOS中较为一致的脑GMV改变,从而揭示EOS可能的病理生理学机制。材料与方法系统地检索PubMed、Web of Science、Embase以及中国知网、万方数据库中采用基于体素的形态学测量(voxel-based morphometry,VBM)方法探究EOS患者与健康对照组之间全脑GMV差异的研究,时间为自建库起至2024年4月30日,提取并汇总EOS患者相对于健康对照者GMV存在显著异常的脑区,并采用基于种子点差异映射和主题图像排列(Seed-based d Mapping with Permutation of Subject Images,SDM-PSI)软件进行数据分析。结果共纳入11项符合标准的研究,样本量共计729例,其中EOS患者366例,健康对照者363例,基于体素的元分析结果表明:EOS患者右侧颞上回(延伸至颞中回及颞极)的GMV显著降低(P<0.005;峰高Z>1;簇范围>10体素),未发现GMV显著增加的脑区。结论本研究通过基于体素的元分析法发现EOS患者较为一致GMV显著异常脑区为右侧颞上回(延伸至右侧颞中回、颞极),这些发现将有助于进一步深化精神分裂症病理生理学机制的理解。Objective:An effective integrative analysis of brain regions with significant gray matter volume(GMV)abnormalities in early-onset schizophrenia(EOS)was conducted to identify the most consistent GMV changes in EOS,thus revealing possible pathophysiologic mechanisms of EOS.Materials and Methods:A systematic searched of the PubMed,Web of Science,Embase,as well as the China Knowledge Network and Wanfang databases for studies that used voxel morphometrics(VBM)to explore the differences in whole-brain GMV between EOS patients and healthy controls were conducted,and the data were analyzed using Seed-based d Mapping with Permutation of Subject Images(SDM-PSI)software,from the time of database establishment until April 30,2024,Brain regions with significant abnormalities in GMV in the patients with EOS relative to healthy controls were extracted and summarized,and the data were analyzed using SDM-PSI software.Results:A total of 11 studies that met the criteria were included,with a total sample size of 729 cases,including 366 patients with EOS and 363 healthy controls.Voxel-based meta-analysis showed that GMV was significantly reduced in the right superior temporal gyrus extending to the right middle temporal gyrus,and temporal pole in patients with EOS,and no brain regions with significantly increased GMV were identified(P<0.005;peak height Z>1;cluster range>10 voxels).Conclusions:In the present study,the voxel-based meta-analysis method revealed that the more consistently GMV significantly abnormal brain region in EOS patients was the right superior temporal gyrus(extending to the right middle temporal gyrus and temporal pole),and these findings will help to further deepen the understanding of the pathophysiological mechanisms of schizophrenia.

关 键 词：早发性精神分裂症 灰质体积 基于体素的形态学测量 磁共振成像 元分析 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.1[医药卫生—诊断学]