MOLLI T1 mapping定量技术在儿童脑发育评估中的应用可行性探讨  

Application of MOLLI T1 mapping quantitative technology in the assessment of pediatric braindevelopment

作　　者：杨雪[1] 贾凤林 马鑫茂 李学胜[1] 李珮 张露 廖怡 宁刚[1] 曲海波[1] YANG Xue;JIA Fenglin;MA Xinmao;LI Xuesheng;LI Pei;ZHANG Lu;LIAO Yi;NING Gang;QU Haibo(Department of Radiology,Key Laboratory of Birth Defects and Related Diseases of Women and Children,Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,China;Department of Operation Management and Evaluation,West China Second University Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西第二医院放射科,出生缺陷与相关妇儿疾病教育部重点实验室,成都610041 [2]四川大学华西第二医院运营管理与评价部,成都610041

出　　处：《磁共振成像》2024年第11期32-38,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家重点研发计划项目(编号:2018YFC1002200);四川省自然科学基金项目(编号:2022NSFSC0830)。

摘　　要：目的探讨改良回顾反转恢复(modified Look-Locker inversion recover,MOLLI)序列T1 mapping定量技术在定量评价儿童脑部发育中的价值。材料与方法纳入头部磁共振检查正常的儿童53例,使用优化后的MOLLI及磁化准备2快速采集梯度回波(magnetization prepared 2 rapid acquisition gradient echoes,MP2RAGE)序列对每例受检者的36个脑区进行T1 mapping定量分析。评价两个序列所得各脑区T1值的一致性,比较两个序列各脑区T1值的差异,分析两个序列各脑区T1值与年龄之间的相关性。结果MOLLI序列和MP2RAGE序列除在双侧脑桥背侧、大脑脚组内相关系数(intra-class correlation coefficient,ICC)<0.8(P<0.001)外,其余脑区ICC均>0.8(P<0.001)。两个序列各脑区的T1值差异均有统计学意义(P<0.05,FDR校正),MOLLI组各脑区T1值高于MP2RAGE组。两个序列各脑区的T1值均与年龄呈负相关(P均<0.001)。结论优化后的MOLLI序列可用于儿童脑部发育的定量评价,与MP2RAGE序列一致性好,可较准确地量化脑区的T1值,为儿童神经系统的研究提供了新的方法选择。Objective:To explore the value of the modified Look-Locker inversion recovery(MOLLI)T1 mapping quantitative technique in evaluating the development of brain in children quantitatively.Materials and Methods:Fifty-three children with normal head magnetic resonance imaging results were included,and optimized MOLLI and magnetization prepared 2 rapid acquisition gradient echoes(MP2RAGE)sequences were used to perform T1 mapping quantitative analysis on 36 brain regions of each subject.We evaluate the consistency of T1 values in each brain region obtained from two sequences,compared the differences in T1 values in each brain region of the two sequences,and analyze the correlation between T1 values in each brain region of the two sequences and age.Results:The intraclass correlation co-efficient(ICC)for the MOLLI sequence and MP2RAGE sequence in all brain regions were greater than 0.8(P<0.001),except for the bilateral dorsal pontine and cerebral peduncle.The differences in T1 values between the two sequences in each brain region were statistically significant(P<0.05,FDR-corrected),the T1 values in each brain region of the MOLLI group were higher than those in the MP2RAGE group.The T1 values of each brain region in both sequences were negatively correlated with age(P<0.001).Conclusions:The optimized MOLLI sequence can be used for the quantitative evaluation of brain development in children,showing good consistency with MP2RAGE sequence,and accurately quantifying T1 values of brain regions,providing a new sequence selection for the study of the nervous system of fetuses and children.

关 键 词：脑发育 儿童 磁共振成像 改良回顾反转恢复序列 T1 mapping 髓鞘 

分 类 号：R445.2[医药卫生—影像医学与核医学] R179[医药卫生—诊断学]