阿尔茨海默病患者血浆标志物及其与磁共振脑影像和认知功能关联的研究进展  

Research progress of plasma biomarkers and the association with MRI neuroimaging and cognitivefunction in patients with Alzheimer's disease

作　　者：葛丹妮 陈夫涛 陈玖 张鑫[1] 张冰[1] GE Danni;CHEN Futao;CHEN Jiu;ZHANG Xin;ZHANG Bing(Department of Medical Imaging,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院医学影像科,南京210008

出　　处：《磁共振成像》2024年第11期142-147,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：科技创新2030—“脑科学与类脑研究”重大项目(编号:2022ZD0211800)。

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)作为最常见的痴呆类型,其特征是脑内淀粉样蛋白斑块沉积和神经纤维缠结,并造成进行性认知下降。血浆生物标志物可反映脑内AD病理改变的特征和严重程度,此外随着神经影像技术的发展,MRI可以阐明AD病理下神经元特定的改变模式,二者在AD的早期诊断中起到愈发重要的作用。本文就AD主要的血浆标志物及其与MRI神经影像、认知功能的关联展开综述,希望能为AD的诊断预测及理解病理机制提供新思路。Alzheimer's disease(AD)is the most common type of dementia,and is characterized by the deposition of amyloid plaques and neurofibrillary tangles in the brain,leading to progressive cognitive decline.Plasma biomarkers reflect the characteristics and severity of AD pathological changes in the brain.In addition,with the development of neuroimaging technology,MRI can clarify the specific patterns of neuronal changes in AD pathology.Both of them play increasingly important roles in the early diagnosis of AD.This article reviews the main plasma biomarkers of AD and their association with MRI neuroimaging and cognitive function,with the aim of offering a novel perspective for the diagnosis,prediction and pathological mechanism understanding of AD.

关 键 词：阿尔茨海默病 血浆生物标志物 神经影像 磁共振成像 认知功能 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.16[医药卫生—诊断学]