重度抑郁症患者脑网络有效连接的磁共振成像研究进展  

Magnetic resonance imaging research progress of effective brain network connectivity in patientswith major depressive disorder

作　　者：孙进楠 伊伟 黄俊霖 任瑞[2] SUN Jinnan;YI Wei;HUANG Junlin;REN Rui(School of Medical Imaging,Binzhou Medical University,Yantai 264003,China;Department of Radiology,Binzhou Medical University Hospital,BinZhou 256603,China)

机构地区：[1]滨州医学院医学影像学院,烟台264003 [2]滨州医学院附属医院放射科,滨州256603

出　　处：《磁共振成像》2024年第11期153-159,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：山东省自然科学基金项目(编号:ZR2022MH118)。

摘　　要：重度抑郁症(major depressive disorder,MDD)是一种以持续悲伤为特征,以精力缺乏、情绪低落、睡眠异常、思维迟缓等为主要表现的精神障碍类疾病。有效连接(effective connectivity,EC)作为一种可以揭示脑区间因果关系的研究方法,在MDD的研究中起着重要作用。本文将对EC分析方法、EC在MDD不同脑网络和重要脑区节点中的研究及临床治疗后变化进行综述,旨在进一步揭示MDD的发病机制以及为治疗靶点的研究提供参考与技术支持。Major depressive disorder(MDD)is a kind of mental disorder characterized by persistent sadness,lack of energy,low mood,abnormal sleep,slow thinking and so on.As a research method that can reveal the causal relationship between brain regions,effective connection(EC)plays an important role in the study of MDD.This article reviews the EC analysis methods,the research of EC in different brain networks and important brain regions of MDD,and the changes of EC after clinical treatment,in order to further reveal the pathogenesis of MDD and provide reference and technical support for the research of therapeutic targets.

关 键 词：重度抑郁症 有效连接 磁共振成像 药物治疗 重复经颅刺激 电休克治疗 深部脑刺激 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.5[医药卫生—诊断学]