细胞程序性死亡在免疫球蛋白A肾病中的研究进展  

Research progress on programmed cell death in immunoglobulin A nephropathy

作　　者：冉英芳 陈彩合 黄文辉[2] RAN Yingfang;CHEN Caihe;HUANG Wenhui(The First Clinical Medical College,Gansu University of Chinese Medicine,Lanzhou,Gansu 730000,P.R.China;Department of Nephrology,Gansu Provincial Hospital,Lanzhou,Gansu 730000,P.R.China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]甘肃省人民医院肾内科,兰州730000

出　　处：《华西医学》2024年第12期1964-1969,共6页West China Medical Journal

基　　金：甘肃省科学技术厅科技计划项目(24JRRA605);甘肃省人民医院院内科研基金项目(22GSSYD-35)。

摘　　要：免疫球蛋白A肾病(immunoglobulin A nephropathy,IgAN)是一种免疫介导的慢性炎症性疾病,其发病机制复杂,临床表现多样,目前尚无特定的治疗方案。细胞程序性死亡是体内由基因所控制的细胞主动的有序的死亡方式,通过参与多种分子信号通路来维持机体的稳态和器官、组织的发育。近年来,细胞程序性死亡在IgAN的发生发展中起着重要的调控作用,其机制涉及复杂的信号通路,在病理条件下可能通过减轻氧化应激、抑制炎症、改善能量代谢等多种途径来缓解肾脏损伤。该文就IgAN在凋亡、自噬、焦亡、铁死亡和铜死亡方面的研究进展作一综述,以期为IgAN提供新的治疗靶点。Immunoglobulin A nephropathy(IgAN)is an immune-mediated chronic inflammatory disease with a complex pathogenesis and diverse clinical manifestations.Currently,there is no specific treatment plan.Programmed cell death is an active and orderly way of cell death controlled by genes in the body,which maintains the homeostasis of the body and the development of organs and tissues by participating in various molecular signaling pathways.In recent years,programmed cell death has played an important regulatory role in the occurrence and development of IgAN,involving complex signaling pathways.Under pathological conditions,it may relieve kidney damage through various pathways such as reducing oxidative stress,inhibiting inflammation,and improving energy metabolism.This article provides a review of the research progress of IgAN in apoptosis,autophagy,pyroptosis,ferroptosis,and cuproptosis in order to provide new therapeutic targets for IgAN.

关 键 词：免疫球蛋白A肾病 凋亡 自噬 焦亡 铁死亡 铜死亡 

分 类 号：R692[医药卫生—泌尿科学]