Effectiveness and safety of adjunctive non-drug measures in improving respiratory symptoms among patients with severe COVID-19:A multicenter randomized controlled trial  

作　　者：Xuan Yin Zhu Jin Feng Li Li Huang Yan-mei Hu Bo-chang Zhu Zu-qing Wang Xi-ying Li Jian-ping Li Lixing Lao Yi-qun Mi Shi-fen Xu 

机构地区：[1]Acupuncture and Moxibustion Department,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China [2]Medical Department,Shanghai Seventh People’s Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China [3]Shanghai Research Institute of Acupuncture and Meridian,Shanghai University of Traditional Chinese Medicine,Shanghai 200030,China [4]Shanghai Xuhui District Central Hospital,Shanghai 200031,China [5]Virginia University of Integrative Medicine,Fairfax,VA 22031,USA

出　　处：《Journal of Integrative Medicine》2024年第6期637-644,共8页结合医学学报（英文版）

基　　金：funded by the Construction Program of Demonstration Centers for TCM Non-Drug Therapy;from Shanghai Municipal Health Commission(No.ZY[2021-2023]-0204)。

摘　　要：Background:The outbreak of coronavirus disease 2019(COVID-19)infection posed a huge threat and burden to public healthcare in late 2022.Non-drug measures of traditional Chinese medicine(TCM),such as acupuncture,cupping and moxibustion,are commonly used as adjuncts in China to help in severe cases,but their effects remain unclear.Objectives:To observe the clinical effect of TCM non-drug measures in improving respiratory function and symptoms among patients with severe COVID-19.Design,setting,participants and interventions:This study was designed as a multicenter,assessor-blind,randomized controlled trial.Hospitalized patients with COVID-19 were randomly assigned to the treatment or control group.The treatment group received individualized TCM non-drug measures in combination with prone position ventilation,while the control group received prone position ventilation only for 5 consecutive days.Main outcome measures:The primary outcome measures were the percentage of patients with improved oxygen saturation(SpO_(2))at the end of the 5-day intervention,as well as changes of patients'respiratory rates.The secondary outcome measures included changes in SpO_(2)and total score on the self-made respiratory symptom scale.The improvement rate,defined as a 3-day consecutive increase in SpO_(2),the duration of prone positioning,and adverse events were recorded as well.Results:Among the 198 patients included in the intention-to-treat analysis,159(80.3%)completed all assessments on day 5,and 39(19.7%)patients withdrew from the study.At the end of the intervention,71(91%)patients in the treatment group had SpO_(2)above 93%,while 61(75.3%)in the control group reached this level.The proportion of participant with improved SpO_(2)was significantly greater in the intervention group(mean difference[MD]=15.7;95%confidence interval[CI]:4.4,27.1;P=0.008).Compared to the baseline,with daily treatment there were significant daily decreases in respiratory rates in both groups,but no statistical differences between groups were found(all P�

关 键 词：Non-drug measures Prone positioning COVID-19 Oxygen saturation Traditional Chinese medicine 

分 类 号：R511[医药卫生—内科学]