聚吡咯基可拉伸导电心肌补片的制备及其电传导性能  

Preparation of polypyrrole-based stretchable conductive myocardial patches and their electroconductive properties

作　　者：李沂蒙 单梦琪 李雯昕 周奉凯 毛吉富 王富军[1,2,3] 王璐[1,2,3] LI Yimeng;SHAN Mengqi;LI Wenxin;ZHOU Fengkai;MAO Jifu;WANG Fujun;WANG Lu(College of Textiles,Donghua University,Shanghai 201620,China;Key Laboratory of Textile Science&Technology,Ministry of Education,Donghua University,Shanghai 201620,China;Shanghai Frontiers Science Center of Advanced Textiles,Donghua University,Shanghai 201620,China)

机构地区：[1]东华大学纺织学院,上海201620 [2]东华大学纺织面料技术教育部重点实验室,上海201620 [3]东华大学上海市现代纺织前沿科学研究基地,上海201620

出　　处：《纺织学报》2024年第12期89-97,共9页Journal of Textile Research

基　　金：上海市自然科学基金面上项目(23ZR1401500);中央高校基本科研业务费专项资金资助项目(2232022A-05);高等学校学科创新引智计划资助项目(BP0719035)。

摘　　要：针对现有导电纤维基心肌补片难以拉伸及其在心脏跳动下电传导失效的问题,通过整合经编成形技术和原位聚合方法,制备了具有不同经编结构的聚吡咯涂层聚丙烯(PP/PPy)导电心肌补片,对补片的微观形貌、化学结构、力学性能、电学性能及其稳定性能、生物学性能等进行研究。结果表明:与变化经平垫纱结构的PP/PPy补片相比,闭口经平结构和衬纬编链结构的PP/PPy补片在拉伸过程中能够通过结构变形实现可拉伸性能;衬纬编链结构的PP/PPy补片展现出与天然心肌组织相似的各向异性导电性能(~10^(-3) S/cm,各向异性比为2.1),并在心脏跳动应变(20%)下表现出稳定的电传导性能(相对电阻变化<0.2);细胞实验证明,PP/PPy补片具有良好的生物相容性。衬纬编链结构的经编心肌补片提供了一种纺织成形的可拉伸结构设计,为各向异性导电补片简便成形提供了新思路。Objective Conductive cardiac patches play a crucial role in the treatment of myocardial infarction(MI).Anisotropic microstructures such as oriented fiber structures have been designed to mimic the directional structure and electrical conductivity of natural myocardial tissue.However,existing conductive fiber-based myocardial repair materials are non-stretchable and can rupture under deformation,hindering the reconstruction of the conductive microenvironment.Therefore,the development of stretchable conductive myocardial patches with anisotropic properties and stable electrical conduction during heartbeats is crucial for effective myocardial repair.Method Polypropylene(PP)patches were immersed in a dopamine solution,followed by treatment with pyrrole and FeCl_(3)·6H_(2)O to obtain PP/PPy samples.Morphological observation was conducted using a stereomicroscope and scanning electron microscope,while chemical composition analysis was performed using a Fourier-transform infrared spectrometer.Mechanical properties were evaluated using a universal material testing machine,and electrical conductivity was measured using a source meter.The resistance changes of patches under stretching strain were assessed using a multi-modal tester.The viability of human foreskin fibroblast cultured with the patches was evaluated using the CCK-8 assay to evaluate the biotoxicity of the patch.Results Optical microscopy images of the knitted patches with different mesh structures were shown(single denbigh stitch,double denbigh derivative tricot stitch with lapping and three denbigh weft laid-in stitch).Scanning electron microscopy(SEM)images reveal the surface morphology of the PP monofilaments before and after PPy coating.The untreated PP monofilaments have a smooth surface,while the PPy-coated PP monofilaments showed roughness due to particle deposition,indicating successful PPy coating.The characteristic peak at 1045 cm-1,attributing to the absorption peak caused by the in-plane C—H vibration of PPy,also confirmed the successful coatin

关 键 词：导电心肌补片 聚吡咯 可拉伸 心肌梗死 经编补片 医用纺织品 

分 类 号：TS181.8[轻工技术与工程—纺织材料与纺织品设计]