电膜萃取技术提取生物检材中滥用药物的研究进展  

Advances in Electromembrane Extraction of Drugs-of-abuse from Biological Samples

作　　者：高同飞 董壮壮 沈先涛 黄垂秀 GAO Tong-fei;DONG Zhuang-zhuang;SHEN Xian-tao;HUANG Chui-xiu(Department of Forensic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Key Laboratory of Environment and Health,Ministry of Education,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院法医学系,湖北武汉430030 [2]华中科技大学同济医学院公共卫生学院教育部环境与健康重点实验室,湖北武汉430030

出　　处：《分析测试学报》2025年第1期25-33,共9页Journal of Instrumental Analysis

基　　金：法庭科学湖北省重点实验室开放课题(KFKT2023016)。

摘　　要：电膜萃取技术(EME)是一种绿色高效的新型样品前处理技术,因其选择性好、净化能力强等优点,近年来被广泛应用于食品分析、环境分析、药物分析以及法医毒物分析领域。该文总结了近五年EME在滥用药物提取中的研究进展,重点总结了EME从不同生物检材(如血液、尿液、唾液、毛发和组织等)中提取富集滥用药物的应用情况,特别关注了其对于毒品、新精神活性物质(NPS)以及临床类滥用药物的分离性能。同时,也探讨了EME应用于法医学领域面临的挑战,并展望了其未来的发展方向。Electromembrane extraction(EME)is a green and efficient microextraction technique,which has been widely applied in all kinds of fields including food analysis,environmental analysis and forensic toxicological analysis in recent years due to the advantages of high selectivity,sufficient sample clean-up capability,and simple in operation.This review summarized the research progress in EME for the separation of drugs-of-abuse over the past five years,with a particular emphasis on its application in extracting and enriching abused drugs from various biological matrices,and paid spe⁃cial attention to the separation performance of EME for illicit drugs,new psychoactive substances(NPS),and addictive pharmaceuticals.Furthermore,this review also examined the challenges faced by EME in its routine application within the field of forensic science and provided a prospective outlook on the future development directions of EME.

关 键 词：电膜萃取 法医毒物分析 样品前处理 滥用药物 毛发 唾液 

分 类 号：O657[理学—分析化学] G353.11[理学—化学]