氟比洛芬酯超前镇痛对腹腔镜子宫切除术患者免疫抑制的影响  

Effect of preemptive analgesia with flurbiprofen ester on immune suppression in patients undergoing laparoscopic hysterectomy

作　　者：苏洁 SU Jie(Department of Anesthesiology,Jin'an District Hospital,Fuzhou 350000,Fujian,China)

机构地区：[1]福州市晋安区医院麻醉科,福建福州350000

出　　处：《外科研究与新技术（中英文）》2024年第4期294-297,共4页Surgical Research and New Technique

摘　　要：目的研究氟比洛芬酯超前镇痛的疗效优势。方法选取2023年4月—2024年4月在福州市晋安区医院行腹腔镜子宫切除术的78例患者,按随机数字表法分为观察组(39例,在患者接受麻醉前采用1 mg/kg氟比洛芬酯加入生理盐水稀释至10 mL后进行静注)和对照组(39例,采用等量生理盐水干预),两组基线资料具有可比性。比较两组间的镇痛效果与安全性。结果插管时及拔管时,观察组患者平均动脉压及心率显著低于对照组(P<0.05)。拔管后1 min、拔管后5 min及离开麻醉监测治疗室时,观察组患者疼痛评分[视觉模拟评分法(VAS)评分]显著低于对照组(P<0.05)。术后1 d,观察组患者外周血炎症因子水平显著低于对照组(P<0.05),T细胞亚群水平则明显高于对照组(P<0.05)。观察组患者术后不良反应总发生率显著低于对照组(P<0.05)。结论对腹腔镜子宫切除术患者施行氟比洛芬酯超前镇痛,能够改善患者平均动脉压及心率,减轻患者疼痛情况,降低患者炎症因子水平并提升细胞免疫水平,减少不良反应的发生,值得临床推广。Objective To study the efficacy advantages of flurbiprofen ester preemptive analgesia.Methods A total of 78 patients who underwent laparoscopic hysterectomy in Jinan District Hospital of Fuzhou City from April 2023 to April 2024 were selected and divided into a control group(39 cases,with an equal amount of saline intervention)and an observation group(39 cases,with intravenous injection of 1 mg/kg flurbiprofen ester diluted to 10 mL of normal saline before anesthesia)by random number table method.Baseline data were comparable between the two groups.Analgesic effect and safety were compared between the two groups.Results The mean arterial pressure and heart rate of patients in the observation group were significantly lower than those of the control group at the time of intubation and extubation(P<0.05).The pain scores[visual analogue scale(VAS)scores]of patients in the observation group were significantly lower than those of the control group at 1 min after extubation,5 min after extubation,and the time of leaving the anesthesia room(P<0.05).The level of inflammatory factors in peripheral blood of the observation group was significantly lower than that of the control group on postoperative day 1(P<0.05),and the level of T cell subsets was significantly higher(P<0.05).The overall postoperative incidence rate of adverse reactions of patients in the observation group was significantly lower than that of the control group(P<0.05).Conclusion The administration of flurbiprofen ester preemptive analgesia to laparoscopic hysterectomy patients is able to improve patients’mean arterial pressure and heart rate,alleviate pain,reduce inflammatory factor levels,increase cellular immunity,and reduce the incidence of adverse reactions.It is worthy of clinical promotion.

关 键 词：氟比洛芬酯超前镇痛 腹腔镜子宫切除术 炎症因子 免疫抑制 

分 类 号：R614.2[医药卫生—麻醉学]