线粒体自噬影响卵巢储备功能减退女性卵母细胞发育的研究进展  

Research progress on the effects of mitophagy on oocyte development in women with diminished ovarian reserve

作　　者：孙娅瑄 马瑞红[1] 马赛花 吴林玲[1] 吴宇 Sun Yaxuan;Ma Ruihong;Ma Saihua;Wu Linling;Wu Yu(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)

机构地区：[1]天津中医药大学第一附属医院国家中医针灸临床医学研究中心,天津300381

出　　处：《中华生殖与避孕杂志》2024年第11期1200-1204,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金面上项目(82374508,82374508);天津中医药大学第一附属医院“拓新工程”基金科研课题重点项目(院ZD202104)。

摘　　要：卵巢储备功能减退(diminished ovarian reserve,DOR)是女性常见的生殖内分泌疾病,是导致女性生育力下降的重要影响因素。DOR女性卵母细胞的数量和质量随年龄增长逐渐下降,从而导致女性出现生育力的减退,其中线粒体功能障碍是造成卵母细胞质量下降的重要诱因。近年来,研究表明线粒体自噬作为细胞内重要的自我修复和代谢平衡机制,与卵母细胞发育密切相关。本文围绕线粒体DNA拷贝数及突变、ATP含量、线粒体活性氧含量、线粒体膜电位变化对线粒体自噬的调控,进而对卵母细胞发育产生的影响及药物对卵母细胞线粒体自噬产生的调节作用展开综述。Diminished ovarian reserve(DOR)is a common reproductive endocrine disease in women,which is an important factor leading to the decline of female fertility.The number and quality of oocytes in DOR women gradually decrease with age,which leads to the decline of fertility in women.Mitochondrial dysfunction is an important cause of oocyte quality decline.In recent years,studies have found that mitophagy,as an important mechanism of self-repair and metabolic balance in cells,is closely related to oocyte development.This article focuses on the regulation of mitochondrial DNA copy number and mutation,ATP content,mitochondrial reactive oxygen species content,mitochondrial membrane potential changes on mitophagy,and the effects on oocyte development and the regulation of drugs on oocyte mitophagy.

关 键 词：线粒体自噬 卵巢储备功能减退 卵母细胞 

分 类 号：R711.75[医药卫生—妇产科学]