颗粒细胞程序性死亡在卵巢衰老中的研究进展  

Progress of programmed death of granulosa cells in ovarian aging

作　　者：孟奕岑 张倩杰 马文静 周忠明[2] 杨菁[1] 李赛姣 Meng Yicen;Zhang Qianjie;Ma Wenjing;Zhou Zhongming;Yang Jing;Li Saijiao(Reproductive Medicine Center,Renmin Hospital of Wuhan University,Hubei Clinical Research Center for Assisted Ferility and Embryo Development,Wuhan 430060,China;Department of Obstetrics and Gynecology,Hubei Provincial Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Traditional Chinese Medicine,Wuhan430060,China)

机构地区：[1]武汉大学人民医院生殖中心、湖北省辅助生育与胚胎发育医学临床研究中心,武汉430060 [2]湖北中医药大学附属湖北省中医院妇产科,武汉430060

出　　处：《中华生殖与避孕杂志》2024年第11期1210-1214,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金青年基金(81701412);湖北省自然科学基金联合基金(2022CFD155);武汉大学研究学分课程建设(2024);湖北省卫生健康科研基金(WJ2021M158);湖北省自然科学基金(2018CFB491)。

摘　　要：卵巢衰老是育龄女性最常见的生殖内分泌疾病之一,发病率逐年上升。其特征为卵巢功能包括卵泡数量和/或质量下降或耗竭,根据卵巢功能下降程度,可分为卵巢储备功能下降、早发性卵巢功能不全、卵巢早衰等疾病,临床表现为排卵障碍、生殖内分泌激素紊乱,并最终导致女性生育力下降。其发病机制复杂多样,迄今为止具体机制尚不清楚。颗粒细胞功能在卵巢激素合成、卵泡发育等过程中作用关键,目前多项研究表明诸多颗粒细胞程序性死亡方式(凋亡、焦亡、自噬、铁死亡、铜死亡等)均可能与卵巢衰老的发生发展密切相关。本文对上述相关文献进行系统综述,旨在探讨颗粒细胞程序性死亡与卵巢衰老的关系。Ovarian aging is one of the most common reproductive endocrine disorders in women of reproductive age,with an increasing incidence over the years.It is characterized by a decline or depletion of ovarian function,including follicle quantity and/or quality.Depending on the degree of ovarian function decline,it can be classified into diseases including diminished ovarian reserve,premature ovarian insufficiency,premature ovarian failure,etc.,which are clinically characterized by ovulatory dysfunction,reproductive endocrine hormone disruption,and ultimately lead to a decline in female fertility.The pathogenesis is complex and varied,and the exact mechanism is unknown to date.Granulosa cells play a key role in ovarian hormone synthesis and disruption development,and many studies have shown that the programmed death of granulosa cells(apoptosis,pyroptosis,autophagy,ferroptosis,cuproptosis,etc.)may be closely related to the occurrence and development of ovarian aging.In this article,we present a systematic review of the relevant literature with the aim of exploring the relationship between programmed cell death in granulosa cells and ovarian aging.

关 键 词：卵巢衰老 颗粒细胞 细胞程序性死亡 卵巢储备功能下降 

分 类 号：R711.75[医药卫生—妇产科学]