PRRSV Nsp1α蛋白结构及生物学功能研究进展  

Research progress on the structure and biological function of PRRSV Nsp1α protein

作　　者：李兴玉[1] 李金海 吴学婧 肖璐 康润敏[1] LI Xingyu;LI Jinhai;WU Xuejing;XIAO Lu;KANG Runmin(Sichuan Animal Science Academy,Chengdu 610066,China;Huapai Biological Group,Chengdu 641402,China)

机构地区：[1]四川省畜牧科学研究院,成都610066 [2]华派生物集团,成都641402

出　　处：《黑龙江畜牧兽医》2024年第23期39-44,共6页Heilongjiang Animal Science And veterinary Medicine

基　　金：四川省区域创新项目(2023YFQ0037,2024YFHZ0110);四川省重大科技专项(2021ZDZX0010);国家现代农业体系四川创新团队建设项目(sccxtd-2024-08);财政运行专项(SASA2024CZYX0006);四川省科技计划项目(2021YFYZ0030)。

摘　　要：猪繁殖与呼吸综合征病毒(Porcine reproductive and respiratory syndrome virus, PRRSV)为有囊膜不分节段单股正链RNA病毒,基因组全长约15 kb,病毒基因组编码11个开放阅读框(open reading frame, ORFs),其中ORF1a编码多聚蛋白pp1a, pp1a通过自身的蛋白酶功能产生Nsp1α、Nsp1β、Nsp2~8蛋白。Nsp1α蛋白被认为是干扰素的拮抗剂,在抑制宿主干扰素产生过程中发挥着重要的作用,还在免疫调节、细胞凋亡等方面发挥作用。文章综述了Nsp1α蛋白结构及其生物学功能的研究进展,以期为PRRSV致病机制的研究及防治猪繁殖与呼吸综合征提供理论支撑。Porcine reproductive and respiratory syndrome virus(PRRSV)is an enveloped and single-strand positive-strand RNA virus.The total length of the genome is about 15 kb,and the viral genome encodes 11 open reading frames(ORFs).Among them,ORF1α encodes the polyprotein ppla,which produces Nsplα,Nsplβ,and Nsp2-8 proteins through its own protease function.Nsplαprotein is considered to be the interferon agent and plays an important role in inhibiting host interferon production.In addition,Nsplαprotein also plays a role in immune regulation and apoptosis.In this paper,the research progress on the structure and biological function of Nsplαprotein was reviewed,in order to provide theoretical support for the study of the pathogenic mechanism,the prevention and treatment of PRRSV.

关 键 词：猪繁殖和呼吸综合征病毒 Nsp1α蛋白 结构 生物学功能 干扰素 

分 类 号：S852.659.6[农业科学—基础兽医学]