HBeAg阳性慢性乙型肝炎患者CD55单核苷酸多态性对聚乙二醇化干扰素α-2b疗效的影响  

Effect of CD55 single nucleotide polymorphism on the efficacy of pegylated interferon α-2b in chronic hepatitis B patients with HBeAg-positive

作　　者：陈继良 周婉月 徐铭晨 CHEN Ji-liang;ZHOU Wan-yue;XU Ming-chen(Department of Laboratory,Sihong First People’s Hospital,Jiangsu 223900,China;Department of Laboratory,Nanjing Medical University Affiliated Suqian First People’s Hospital,Suqian,Jiangsu 223899,China;Department of Infectious Diseases,Sihong First People’s Hospital,Jiangsu 223900,China)

机构地区：[1]泗洪县第一人民医院检验科,江苏223900 [2]泗洪县第一人民医院感染科,江苏223900 [3]南京医科大学附属宿迁第一人民医院检验科,223899

出　　处：《肝脏》2024年第11期1374-1377,1381,共5页Chinese Hepatology

基　　金：江苏省卫生健康委基金项目(ZD2022041)。

摘　　要：目的 探讨CD55单核苷酸多态性(CD55-SNP)对HBeAg阳性慢性乙型肝炎(CHB)接受聚乙二醇化干扰素α-2b(Peg-IFNα-2b)治疗的影响。方法 选取2017年8月—2021年8月期间入院诊治HBeAg阳性CHB患者159例。根据HBV DNA<2000 IU/mL且HBsAg和抗-HBe血清转换者结果分为应答组(87例)和非应答组(72例)。回顾性分析两组患者的临床资料,探究CD55-SNP对患者治疗的影响。结果 CD55-rs28371597在应答组的GG基因(91.4%)明显高于CT基因(6.4%)和TT基因(3.2%),CFB-rs12614 CC基因(92.4%)显著高于CT基因(7.6%)和TT基因,(0%),STAT4-rs7574865 GG基因(52.6%)明显高于GT基因(38.1%)和TT基因(9.3%)。与非应答组(75.0%、79.1%)相比,应答组的CD55-rs28371597 GG基因(91.4%)和CFB-rs12614 CC基因(92.4%)升高。对患者根据治疗效果的影响因素进行分析,两组患者的饮酒、CD55-rs28371597基因型比较差异有统计学意义。HBV DNA、CFB-rs12614和STAT4-rs7574865经多变量校正发现不影响治疗结局,差异无统计学意义(P>0.05),而CD55-rs28371597显著影响治疗结局(P<0.05)。结论 CD55-SNP多态性影响HBeAg阳性CHB患者接受治疗Peg-IFNα-2b的疗效,且与病毒学应答紧密相关,临床医生可根据CD55-SNP多态性分布情况,预测Peg-IFNα-2b治疗效果,给予合理的治疗方案。Objective To investigate the effect of CD55 single nucleotide polymorphism(CD55-SNP)on the efficacy of pegylated interferonα-2b(Peg-IFNα-2b)in chronic hepatitis B(CHB)patients with HBeAg-positive.Methods From August 2017 to August 2021,159 CHB patients with HBeAg-positive were selected.According to the results,CHB patients were divided into response group and non-response group.The clinical data of the two groups were retrospectively analyzed to explore the effect of CD55-SNP on the treatment of patients.Results The GG gene(91.4%)of CD55-rs28371597 was significantly higher than that of CT gene(6.4%)and TT gene(3.2%),and the CFB-rs12614 CC gene(92.4%)was significantly higher than that of CT gene(7.6%)and TT gene(0%)in the response group.Compared with the non-response group(75.0%,79.1%),the CD55-rs28371597 GG gene(91.4%)and CFB-rs12614 CC gene(92.4%)in the response group increased.According to the analysis of the influencing factors of the treatment effect,the comparison of drinking and CD55-rs28371597 genotype between the two groups was statistically significant.After multivariate calibration,HBV DNA,CFB-rs12614 and STAT4-rs7574865 did not affect the treatment outcome(P>0.05),while CD55-rs28371597 significantly affected the treatment outcome(P<0.05).Conclusion CD55-SNP polymorphism affects the efficacy of Peg-IFNα-2b in CHB patients with HBeAg-positive,and is closely related to virological response.Clinicians can predict the therapeutic effect of Peg-IFNα-2b according to the distribution of CD55-SNP polymorphism and give a reasonable treatment plan.

关 键 词：CD55单核苷酸多态性 HBEAG 慢性乙型肝炎 聚乙二醇化干扰素α-2b 疗效 

分 类 号：R512.62[医药卫生—内科学]