双合枣仁颗粒对慢性睡眠障碍共病负性情绪的影响  

Effect of Shuanghe Zaoren granules on co-morbid negative emotions of chronic sleep disorders

作　　者：杨雄杰[1] 汪刘根[1] 吴洪雷[1] 曲玉强[1] 左扁头[1] 刘锐 韩志强 黄露 YANG Xiongjie;WANG Liugen;WU Honglei;QU Yuqiang;ZUO Biantou;LIU Rui;HAN Zhiqiang;HUANG Lu(Wuhu Hospital of Traditional Chinese Medicine,Anhui Province,Wuhu 241000,China)

机构地区：[1]安徽省芜湖市中医医院,241000

出　　处：《临床合理用药》2025年第1期8-12,共5页Chinese Journal of Clinical Rational Drug Use

基　　金：安徽省高校自然科学科研重大项目(2022AH040329);安徽中医药高等专科学校自然科学科研项目(ZRKXY202010)。

摘　　要：目的观察双合枣仁颗粒对慢性睡眠障碍共病负性情绪的影响。方法选取2020年1—12月芜湖市中医医院门诊和住院诊治的慢性睡眠障碍共病负性情绪患者80例,采用随机数字表法分为观察组和对照组,每组40例。对照组采用舒肝解郁胶囊干预,观察组在对照组基础上加用双合枣仁颗粒干预,2组均干预3周。比较2组干预前后匹兹堡睡眠质量量表(PSQI)评分、汉密尔顿焦虑量表(HAMA)评分、中医证候积分,临床治愈率及安全性。结果干预3周后,2组PSQI各项评分及总分均低于干预前,且观察组睡眠质量、入睡时间、睡眠时间、睡眠效率、日间功能评分及PSQI总分低于对照组(P<0.01),2组睡眠障碍与催眠药物评分比较差异无统计学意义(P>0.05);2组躯体焦虑因子、精神焦虑因子评分及HAMA总分均低于干预前,且观察组低于对照组(P<0.01);2组各项中医证候积分及总分均低于干预前,且观察组入睡困难、睡而易醒、醒后难睡、整夜不眠、急躁易怒、头晕头胀积分及总分低于对照组(P<0.05或P<0.01),而2组目赤耳鸣、口干而苦、多梦、舌苔、脉象积分比较差异无统计学意义(P>0.05)。以PSQI评分为标准,干预3周后,观察组临床治愈率为37.50%,对照组临床治愈率为20.00%,2组比较差异无统计学意义(χ^(2)=2.990,P=0.084);以HAMA评分为标准,干预3周后,观察组临床治愈率为95.00%,高于对照组的50.00%(χ^(2)=20.313,P<0.001)。干预过程中,2组患者血尿便常规、心电图及肝肾功能等指标均未见异常。结论慢性睡眠障碍共病负性情绪患者采用双合枣仁颗粒干预,可缩短入睡时间,提高睡眠效率和质量,改善负性情绪,提高临床治愈率,且安全性较高。Objective To observe the effect of Shuanghe Zaoren granules on co-morbid negative emotions of chronic sleep disorders.Methods Eighty patients with co-morbid negative emotions of chronic sleep disorders in the outpatient and inpatient clinics of Wuhu Hospital of Traditional Chinese Medicine from January to December 2020 were selected,and they were divided into the observation group and the control group by using the random number table method,40 cases in each group.The control group was treated with Shugan Jieyu capsule,and the observation group was treated with Shuanghe Zaoren granules on the basis of the control group,and both groups were intervened for 3 weeks.The PSQI scores,HAMA scores,TCM syndrome scores before and after the intervention,and the clinical cure rate and safety were compared between the two groups.Results After 3 weeks of intervention,the PSQI scores and total scores of the two groups were lower than those before intervention,and sleep quality,sleep onset latency,total sleep duration,sleep efficiency,daytime functioning scores and total PSQI scores of the observation group were lower than those of the control group(P<0.01),and the difference between the sleep disorders of the two groups compared with the scores of hypnotic drugs was not statistically significant(P>0.05).The scores of somatic anxiety factor,mental anxiety factor and total HAMA score of the two groups were lower than that before intervention,and the observation group was lower than that of the control group(P<0.01).TCM syndrome scores in the two groups were lower than those before the intervention,and the points and total scores of the observation group were lower than those of the control group in terms of difficulty in falling asleep,easy to wake up from sleep,difficult to fall asleep after waking up,sleeplessness throughout the night,impatience and irritability,dizziness and head distension(P<0.05 or P<0.01),and the difference between the points of red eyes and tinnitus,dry and bitter mouth,dreaminess,tongue coating,and pulse

关 键 词：慢性睡眠障碍 负性情绪 双合枣仁颗粒 睡眠质量 焦虑 

分 类 号：R277.7[医药卫生—中医学]