当归拈痛汤治疗急性痛风性关节炎的临床效果及安全性  

Clinical effect and safety of Danggui Niantong decoction in the treatment of acute gouty arthritis

作　　者：李幸 张丽霞 段润章 张天禄 LI Xing;ZHANG Lixia;DUAN Runzhang;ZHANG Tianlu(Department of Rheumatology,Dali Bai Autonomous Prefecture Chinese Medicine Hospital,Yunnan Province,Dali 671000,China)

机构地区：[1]大理白族自治州中医医院风湿病科,云南省大理市671000

出　　处：《临床合理用药》2025年第1期38-41,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察当归拈痛汤治疗急性痛风性关节炎的临床效果及安全性。方法选取2021年5月—2023年4月大理白族自治州中医医院收治的急性痛风性关节炎患者63例,依据随机数字表法分为研究组32例和对照组31例。对照组给予常规西医治疗,研究组在对照组基础上给予当归拈痛汤治疗,2组连续治疗1周后比较疗效,治疗前后中医证候积分、血清C反应蛋白(CRP)水平、红细胞沉降率(ESR)、视觉模拟评分法(VAS)评分、骨关节炎指数(WOMAC)评分、Oswestry功能障碍指数(ODI)评分及不良反应。结果研究组治疗总有效率为93.75%,高于对照组的70.97%(χ^(2)=5.671,P=0.017)。治疗1周后,2组皮肤色红、局部皮温、关节肿胀、关节疼痛积分均低于治疗前,且研究组低于对照组(P<0.01);2组血清CRP水平及ESR均低于治疗前,且研究组低于对照组(P<0.01);2组VAS、WOMAC、ODI评分均低于治疗前,且研究组低于对照组(P<0.01)。研究组与对照组不良反应总发生率比较差异无统计学意义(0 vs.3.23%,P=0.987)。结论当归拈痛汤治疗急性痛风性关节炎效果较好,可有效缓解临床症状,下调血清炎性因子水平,改善疼痛及病情程度,且不良反应少。Objective To observe the clinical effect and safety of Danggui Niantong decoction in the treatment of acute gouty arthritis.Methods A total of 63 patients with acute gouty arthritis admitted to Dali Bai Autonomous Prefecture Chinese Medicine Hospital from May 2021 to April 2023 were selected and divided into the study group(32 cases)and the control group(31 cases)according to the random number table method.The control group was treated with conventional western medicine,and the study group was treated with Danggui Niantong decoction on the basis of the control group.The curative effect,TCM syndrome score,serum CRP level,ESR,VAS score,WOMAC score,ODI score before and after treatment,and adverse reactions were compared between the two groups after continuous treatment for 1 week.Results The total effective rate of the study group was 93.75%,which was higher than 70.97%of the control group(χ^(2)=5.671,P=0.017).After 1 week of treatment,the scores of skin redness,local skin temperature,joint swelling and joint pain in the two groups were lower than those before treatment,and the study group were lower than those in the control group(P<0.01).The levels of serum CRP and ESR in the two groups were lower than those before treatment,and the study group were lower than those in the control group(P<0.01).The VAS,WOMAC and ODI scores of the two groups were lower than those before treatment,and the study group were lower than those of the control group(P<0.01).There was no significant difference in the total incidence of adverse reactions between the study group and the control group(0 vs.3.23%,P=0.987).Conclusion Danggui Niantong decoction is effective in the treatment of acute gouty arthritis,which can effectively relieve clinical symptoms,down-regulate serum inflammatory factors,improve pain and disease severity,and has fewer adverse reactions.

关 键 词：急性痛风性关节炎 当归拈痛汤 临床效果 安全性 

分 类 号：R259[医药卫生—中西医结合]