振动辅助排痰配合乙酰半胱氨酸雾化吸入治疗婴幼儿肺炎的临床效果  

Efficacy of combined vibration-assisted sputum excretion and acetylcysteine nebulization in the treatment of infant pneumonia

作　　者：刘小松 刘梦奇 LIU Xiaosong;LIU Mengqi(Pediatrics Department,Pingxiang Maternal and Child Care,Jiangxi Province,Pingxiang 337000,China)

机构地区：[1]江西省萍乡市妇幼保健院儿内一科,337000

出　　处：《临床合理用药》2025年第2期31-34,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：萍乡市卫生健康新技术引进项目(2021PY199)。

摘　　要：目的观察振动辅助排痰配合乙酰半胱氨酸雾化吸入治疗婴幼儿肺炎的临床效果。方法选取2021年8月—2022年8月萍乡市妇幼保健院儿内一科收治的肺炎患儿80例,采用随机数字表法分为观察组和对照组,各40例。2组患儿均予常规治疗,对照组在常规治疗基础上加用吸入用乙酰半胱氨酸溶液治疗,观察组在对照组基础上配合振动辅助排痰,2组患儿均治疗7 d。比较2组临床效果、症状体征(发热、咳嗽、气喘、肺部湿性啰音)消失时间、住院时间、住院费用,治疗前后血常规指标[白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)]水平以及不良反应。结果观察组治疗总有效率为97.50%,高于对照组的85.00%(χ^(2)=3.914,P=0.048);观察组发热、咳嗽、气喘消失时间、肺部湿性啰音消失时间及住院时间均短于对照组,住院费用低于对照组(P<0.01);治疗7 d后,2组WBC及血清CRP、PCT水平均较治疗前下降,且观察组低于对照组(P<0.01);观察组与对照组不良反应总发生率(12.50%vs.10.00%)比较差异无统计学意义(χ^(2)=0.125,P=0.723)。结论振动辅助排痰配合乙酰半胱氨酸雾化吸入治疗婴幼儿肺炎的临床效果较好,可有效缓解患儿症状表现与炎性反应程度,且安全性较高。Objective To investigate the clinical efficacy of vibration-assisted sputum excretion combined with acetylcysteine nebulization in infants with pneumonia.Methods Eighty pediatric patients with pneumonia admitted to Pingxiang Maternal and Child Care from August 2021 to August 2022 were randomly divided into observation group(n=40)and control group(n=40)using a random number table.The control group received standard care plus acetylcysteine solution for inhalation,while the observation group received vibration-assisted sputum excretion in addition to the control group treatment.Both groups were treated for 7 days.The study compared the clinical efficacy,time to resolution of symptoms(fever,cough,wheezing,crackles),length of hospital stay,hospitalization costs,changes in blood routine indicators(WBC,CRP,PCT)before and after treatment,and adverse events between the two groups.Results The overall effective rate was significantly higher in the observation group(97.50%)compared to the control group(85.00%)(χ^(2)=3.914,P=0.048).The observation group showed shorter durations of fever,cough,wheezing,crackles,as well as a shorter length of hospital stay and lower hospitalization costs compared to the control group(all P<0.01).After 7 days of treatment,both groups showed significant decreases in WBC,CRP,PCT levels compared to baseline,with the observation group showing a more pronounced decrease(P<0.01).There was no significant difference in the overall incidence of adverse events between the observation group(12.50%)and the control group(10.00%)(χ^(2)=0.125,P=0.723).Conclusion The combined use of vibration-assisted sputum excretion and acetylcysteine nebulization showed superior clinical outcomes in treating infant pneumonia,effectively reducing symptoms and inflammation,while maintaining a high safety profile.

关 键 词：婴幼儿肺炎 乙酰半胱氨酸 振动辅助排痰 治疗效果 

分 类 号：R725.6[医药卫生—儿科]