静脉麻醉药在脑缺血再灌注损伤中的研究进展  

Progress of Intravenous Anesthetics in Cerebral Ischemia-reperfusion Injury

作　　者：曾晗玉 Hanyu Zeng(Graduate School,North China University of Science and Technology,Tangshan,Hebei 063000)

机构地区：[1]华北理工大学研究生学院,河北唐山063000

出　　处：《医学研究前沿》2024年第9期19-21,共3页Frontiers of Medical Research

摘　　要：探讨了脑缺血再灌注损伤的多种机制,如细胞凋亡、细胞坏死、自噬及铁死亡等,特别是p53介导的坏死和自噬失控对神经细胞的损伤。重点研究了静脉麻醉药环泊酚和丙泊酚的神经保护作用,发现它们可通过AMPK等信号通路减轻脑缺血再灌注损伤,为开发新的治疗策略提供了理论依据。We explored various mechanisms of cerebral ischemia-reperfusion injury,such as apoptosis,cell necrosis,autophagy and iron death,especially the damage of nerve cells caused by p53-mediated necrosis and uncontrolled autophagy.We focused on the neuroprotec-tive effects of the intravenous anesthetic cyclic and propofol and found that they could reduce cerebral ischemia-reperfusion injury through signaling pathways such as AMPK,which provided a theoretical basis for the development of new therapeutic strategies.

关 键 词：脑缺血再灌注损伤 环泊酚 丙泊酚 铁死亡 

分 类 号：R651.1[医药卫生—外科学]