河南辉县地区30~79岁人群吸烟与心血管疾病发病风险的前瞻性研究  

Prospective study on smoking status and the risk of cardiovascular disease among Huixian resident aged 30-79 years,Henan

作　　者：席瑾[1] 孙花荣 姜琳珂 杜永芳[1] 冯石献[3] 栾旭波[1] 穆永娟 郭晓新 裴培 孙点剑一 XI Jin;SUN Hua-rong;JIANG Lin-ke;DU Yong-fang;FENG Shi-xian;LUAN Xu-bo;MU Yong-juan;GUO Xiao-xin;PEI pei;SUN Dian-jian-yi(Xinxiang Center for Disease Control and Prevention,Xinxiang,Henan 453000,China;不详)

机构地区：[1]河南省新乡市疾病预防控制中心,河南新乡453000 [2]河南省新乡市辉县疾病预防控制中心 [3]河南省疾病预防控制中心 [4]北京大学公众健康与重大疫情防控战略研究中心 [5]北京大学公共卫生学院流行病与卫生统计学系 [6]重大疾病流行病学教育部重点实验室(北京大学)

出　　处：《现代预防医学》2024年第24期4429-4434,共6页Modern Preventive Medicine

基　　金：国家自然科学基金(82192900,82192901,82192904,81390540,91846303),国家重点研发计划精准医学研究重点专项(2016YFC0900500);香港Kadoorie Charitable基金;英国Wellcome Trust(202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z)。

摘　　要：目的河南辉县居民吸烟与心血管病发病风险关联度分析。方法利用中国慢性病前瞻性研究项目在河南辉县地区招募的30~79岁研究对象的基线调查和随访数据,使用Cox比例风险回归模型分析研究人群不同吸烟状况与心血管疾病发病风险的关联。结果共纳入59865例研究对象,累积随访586851.81年,平均随访时间9.20年,随访期间新发心血管疾病17142例,缺血性心脏病5959例,缺血性脑卒中7717例,出血性脑卒中1387例。男性吸烟率(65.29%)远高于女性(0.34%)。多因素分析结果显示,与非吸烟者相比,吸烟能增加心血管疾病(HR=1.178,95%CI:1.118~1.241)的发病风险,尤其是缺血性心脏病(HR=1.291,95%CI:1.177~1.417)和缺血性脑卒中(HR=1.297,95%CI:1.203~1.398);在当前规律吸烟者中,每日吸烟量(支/日)≥20支者和开始吸烟年龄<20岁者发生心血管疾病、缺血性心脏病、缺血性脑卒中的风险较高。结论吸烟能增加心血管疾病的发病风险,应加强对吸烟行为的控制和干预,遏制我国心血管疾病的流行趋势。Objective To analyze the relationship between smoking status and risk of cardiovascular diseases among Henan Huixian residents.Methods The baseline survey data and follow-up data of participants aged 30-79 years recruited in Huixian County,Henan,through the China Chronic Disease Prospective Research Project were used.Cox proportional hazard regression models were used to analyze the association between smoking status and risk of cardiovascular diseases.Results A total of 59865 cases were included in the cohort and followed up for a total of 586851.81 person years(average 9.20 years).We documented 17142 cases of cardiovascular diseases,5959 cases of ischemic heart diseases,7717 cases of cerebral infarction and 1387 cases of intracerebral hemorrhage.The smoking rate of men(65.29%)was much higher than that of women(0.34%).Cox multivariate analysis showed,compared with nonsmokers,current smokers had higher risk of cardiovascular diseases(HR=1.178,95%CI:1.118-1.241),ischemic heart diseases(HR=1.291,95%CI:1.177-1.417)and cerebral infarction(HR=1.297,95%CI:1.203-1.398).Among current smokers,those who smoked more than 20 cigarettes per day or those who started smoking at the age of less than 20 years old had higher risk of cardiovascular diseases,ischemic heart diseases and cerebral infarction.Conclusion Smoking can effectively decrease the risk of cardiovascular diseases.It is necessary to strengthen the control and intervention of smoking behavior in order to curb the epidemic trend of cardiovascular disease.

关 键 词：吸烟 心血管疾病 队列研究 

分 类 号：R54[医药卫生—心血管疾病] R51[医药卫生—内科学]