重庆市渝北区新报告50岁及以上人群HIV-1基因型及分子传播网络特征分析  

Analysis of HIV-1 genotypes and molecular transmission network among newly reported HIV/AIDS cases aged 50 and above in Yubei District of Chongqing

作　　者：刘惠[1] 李荻菲 黄歆 叶茂 孙松松 LIU Hui;LI Di-fei;HUANG Xin;YE Mao;SUN Song-song(Chongqing Yubei District Center for Disease Control and Prevention,Chongqing 401120,China)

机构地区：[1]重庆市渝北区疾病预防控制中心,重庆401120

出　　处：《现代预防医学》2024年第24期4567-4572,4596,共7页Modern Preventive Medicine

基　　金：2023年重庆市公共卫生重点专科(学科)建设项目,重庆市渝北区科卫联合项目(2023YBKW13)。

摘　　要：目的分析重庆市渝北区新报告50岁及以上人群HIV-1基因型及分子传播网络特征,为该地区有效干预HIV传播提供科学参考依据。方法收集2022—2023年新报告的50岁及以上HIV/AIDS血液样本用于基因分析,通过计算Pol区基因距离构建分子网络,对研究对象进入网络的相关因素及成簇病例特征进行分析。结果获得351条Pol区基因序列,共检测出9种HIV-1基因型,CRF07_BC是最主要的传播亚型,占57.0%(200/351),其次为CRF08_BC占19.4%(68/351),共有201条序列进入网络,入网率为57.3%,形成44个簇,簇内的节点数介于2~25个之间。60岁及以上(60~69岁:aOR=2.25,95%CI:1.34~3.80;70~79岁:aOR=2.93,95%CI:1.52~5.65)、渝北本地户籍(aOR=3.10,95%CI:1.74~5.52)、基因型为CRF07_BC(aOR=2.57,95%CI:1.47~4.50)更容易入网。高风险传播者在男性中的比例高于女性。结论渝北区新报告50岁及以上HIV/AIDS的HIV-1基因型以CRF07_BC、CRF08_BC为主,传播风险较高的重点传播簇基因型为CRF07_BC,应针对老年人高风险者加强干预,动态监测分子网络,指导精准干预。Objective To analyze the genotypes and characteristics of HIV-1 transmission network of newly reported HIV/AIDS cases aged 50 and above in Yubei District of Chongqing and provide evidence for effective HIV-1 transmission prevention in Yubei District.Methods Blood sample of newly reported cases aged 50 and above in 2020-2023 were collected for genetic analysis,partial Pol gene sequences were obtained to construct molecular transmission network.The factors associated with the subjects entering network and characteristics of cluster were further analyzed.Results A total of 351 Pol gene sequences were obtained and 9 HIV-1 genotypes were detected.CRF07_BC(57.0%,200/351)was the major subtypes,followed by CRF08_BC(19.4%,68/351),the rate of network entry was 57.3%,and 44 clusters were formed.The number of nodes in clusters was between 2-25.People aged 60 and above(60-69years old:aOR=2.25,95%CI:1.34-3.80;70-79years old:aOR=2.93,95%CI:1.52-5.65),with local household registration in Yubei(aOR=3.10,95%CI:1.74-5.52)and genotype CRF07_BC(aOR=2.57,95%CI:1.47-4.50)were more likely to have internet access.The proportion of high-risk spreaders was higher among males than among females.Conclusion CRF07_BC and CRF08_BC are the major genotypes of HIV/AIDS in people aged 50 years and abovein Yubei District,and CRF07_BC is the genotype of key transmission cluster with high transmission risk.We should strengthen the intervention for the high-risk elderly,and monitor the molecular network dynamically to guide the precise intervention.

关 键 词：50岁及以上人群 艾滋病病毒 基因型 分子传播网络 

分 类 号：R512.91[医药卫生—内科学]