产科弥散性血管内凝血及其评分系统的研究现状  

Current research status on obstetric disseminated intravascular coagulation and its scoring system

作　　者：刘子洋 崔俭俭 赵茵[1,2] Ziyang Liu;Jianjian Cui;Yin Zhao(Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China;Research Institute of Huazhong University of Science and Technology in Shenzhen,Shenzhen 518000,Guangdong Province,China)

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科,武汉430022 [2]深圳华中科技大学研究院,深圳518000

出　　处：《中华妇幼临床医学杂志（电子版）》2024年第5期511-518,共8页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家自然科学基金项目(82171678);深圳市自然科学基金项目(JCYJ20200109140614667);深圳市自然科学基金面上项目(JCYJ20230807143504009)。

摘　　要：产科弥散性血管内凝血(DIC)是产科严重并发症之一,具有临床表现多样、疾病进展快速、凝血功能异常复杂等特点,极大增加了早期诊断和治疗难度。临床对产科DIC的诊断,主要依据患者基础疾病与特征性临床表现及实验室检查结果等进行综合判断,早期识别和正确干预是该病患者良好预后的关键。产科DIC评分系统具有便捷、精准、直观、可定量等优点,在产科DIC临床诊断中发挥重要作用。目前国内外有不同的产科DIC评分系统。笔者拟就产科DIC定义、孕妇发病率及不良结局,孕期生理性高凝状态,产科DIC发病机制及病理特点与孕妇临床表现及实验室检查指标,以及产科DIC诊断标准及评分系统演变的最新研究现状进行系统阐述,旨在为产科DIC的临床诊治提供参考。Disseminated intravascular coagulation(DIC)in obstetrics is one of the serious complications,characterized by diverse clinical manifestations,rapid disease progression,and complex of coagulation dysfunction,which greatly increase the difficulty of early diagnosis and treatment of pregnant women with DIC.The diagnosis of obstetrics DIC is mainly relied on a comprehensive assessment of the underlying diseases,characteristic clinical manifestations,and laboratory test results,while the key to a good prognosis of obstetrics DIC pregnant women lies on early identification and appropriate intervention.DIC scoring system in obstetrics came into being as a convenient,accurate,intuitive and quantifiable diagnostic method.At present,there are different obstetric DIC scoring systems both domestically and internationally.The author intends to systematically elaborate the definition of obstetric DIC,incidence and adverse outcomes of pregnant women and puerpera,and their children,physiological hypercoagulability during pregnancy,pathogenesis and pathological characteristics of obstetric DIC,clinical manifestations and laboratory indicators of pregnant women and puerpera,as well as the latest research status of the evolution of diagnostic criteria and scoring system for obstetric DIC,in order to provide reference for clinical diagnosis and treatment of obstetric DIC patients.

关 键 词：弥漫性血管内凝血 抗凝血酶类 凝血酶时间 纤维蛋白原 妊娠并发症 血液凝固障碍 部分促凝血酶原时间 评分系统 孕产妇 

分 类 号：R714[医药卫生—妇产科学]