全氟及多氟烷基化合物暴露与儿童肥胖症相关性研究现状  

Current research status of correlation between per-and polyfluoroalkyl substances exposure and childhood obesity

作　　者：向韵 卢游 杨凡 Yun Xiang;You Lu;Fan Yang(Department of Pediatrics,Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2024年第5期569-574,共6页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家重点研发计划项目子课题(2019YFC0840702-01);四川省医学会青年创新科研项目(Q20016)。

摘　　要：肥胖症(obesity)是一种慢性营养障碍性疾病,由遗传、环境、饮食、行为、疾病、药物等多种因素所致,是21世纪最严重的公共卫生挑战之一。儿童期肥胖将增加个体成年后罹患心血管疾病、糖尿病、肌肉骨骼疾病及某些癌症的风险。全氟及多氟烷基化合物(PFAS)属于环境内分泌干扰物(EED),是一类人工合成的庞大脂肪烃类化合物,从20世纪40年代开始被广泛使用,PFAS理化性质稳定,对人体有多种毒性作用。目前已有大量实验及流行病学研究结果表明,儿童PFAS暴露与儿童肥胖症的发生密切相关。笔者拟就PFAS暴露现状及其与儿童肥胖症的关联性,以及PFAS对机体糖代谢及脂代谢异常的作用机制与儿童肥胖症关系的最新研究现状进行阐述。Obesity is a chronic nutritional disorder caused by multiple factors,such as genetics,environment,diet,behavior,diseases,and medications.It is one of the most significant public health challenges of the 21st century.Childhood obesity i ncreases the risk of developing cardiovascular diseases,diabetes,musculoskeletal disorders,and certain types of cancer in adulthood.Per-and polyfluoroalkyl substances(PFAS)are classified as environmental endocrine disruptors(EED)and consist of a large synthetic fluorinated hydrocarbon compounds that have been used since the 1940s.They have stable physicochemical properties and exert various toxic effects on the human body.Currently,a large number of experimental and epidemiological research results have shown that children's exposure to PFAS is closely related to the occurrence of childhood obesity.This article will provide a comprehensive review of the latest research progress on the relationship between PFAS exposure and childhood obesity,the relationship between PFAS's mechanism on abnormal glucose and lipid metabolism and childhood obesity.

关 键 词：肥胖症 氟烷 氟化合物 内分泌干扰物 脂类代谢 葡萄糖代谢障碍 儿童 

分 类 号：R589.2[医药卫生—内分泌]