高性能慢性伤口敷料的研究进展  

Progress in Research on High-Performance Chronic Wound Dressings

作　　者：沈佳斌[1] 朱怡蓉 杨金花 覃靖娴 韩颜庭 SHEN Jiabin;ZHU Yirong;YANG Jinhua;QIN Jingxian;HAN Yanting(State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu 610065,Sichuan;Medicine and Engineering Interdisciplinary Research Laboratory of Nursing&Materials,West China School of Nursing,West China Hospital,Chengdu 610041,Sichuan)

机构地区：[1]四川大学高分子材料工程国家重点实验室/高分子研究所,四川成都610065 [2]四川大学华西医院护理与材料医工交叉研究室/华西护理学院,四川成都610041

出　　处：《四川师范大学学报（自然科学版）》2025年第2期143-153,F0002,共12页Journal of Sichuan Normal University（Natural Science）

基　　金：国家自然科学基金(52403043);四川省科技厅杰出青年人才项目(2022JDJQ0023);高分子材料工程国家重点实验室课题基金(sklpme2021-4-06)。

摘　　要：慢性伤口愈合是一个复杂且耗时的过程,容易受到大肠杆菌、金黄色葡萄球菌等微生物的攻击.传统敷料如棉花、纱布等,其屏障作用较差,导致伤口容易被细菌侵入,在愈合过程中其纤维会黏附在新生的肉芽组织上,频繁换药会加剧患者痛苦甚至导致二次创伤,并且对创面愈合无明显促进作用.近十年来,新型创面敷料的相关研究不断涌现,这些敷料可以与伤口相互作用,其中的智能敷料还可以通过内置传感器或智能材料(如刺激响应材料和自修复材料)感知和反应伤口状况或环境变化,赋予伤口敷料智能响应释药的功能,从而有效促进伤口愈合.基于此,综述伤口敷料领域的研究进展,同时总结相关性能表征方法,并简要展望该领域的未来研究方向.Chronic wound healing is a complex and time-consuming process that is susceptible to attack by microorganisms such as Escherichia coli and Staphylococcus aureus.Traditional dressings,such as cotton and gauze,have a poor barrier effect,resulting in wounds that are easily invaded by bacteria,and their fibers adhere to the nascent granulation tissue during the healing process,and frequent dressing changes can exacerbate the patient s pain or even lead to secondary trauma,and do not significantly contribute to wound healing.In the past decade,research on new wound dressings has been emerging,and these dressings can interact with wounds,and smart dressings can also sense and respond to wound conditions or environmental changes through built-in sensors or smart materials(e.g.,stimulus-responsive materials and self-repairing materials),which can give wound dressings the function of releasing drugs in response to the wounds,and thus effectively promote wound healing.Based on this,this paper reviews the research progress in the field of wound dressings,summarizes the relevant characterization methods,and briefly outlines the future research direction in this field.

关 键 词：伤口敷料 伤口愈合 敷料性能 

分 类 号：R318[医药卫生—生物医学工程]