Role of dsRNA-Based Insecticides in Agriculture:Current Scenario and Future Prospects  

作　　者：Pratyush Kumar Das Satyabrata Nanda 

机构地区：[1]Department of Phytopharmaceuticals,School of Agricultural and Bioengineering(SoABE),Centurion University of Technology and Management,Paralakhemundi,761211,India [2]School of Biotechnology,Centurion University of Technology and Management,Bhubaneswar,752050,India

出　　处：《Phyton-International Journal of Experimental Botany》2024年第12期3217-3235,共19页国际实验植物学杂志（英文）

摘　　要：Insect pests cause severe crop damage,resulting in substantial economic losses and threats to global food security.Conventional insecticides are low-cost chemical agents that kill the target insects and some non-specific beneficial organisms.Due to their toxic and non-biodegradable nature,these conventional insecticides persist in the environment,thus causing pollution and accumulating in the food chain.The development of novel insecticidal products based on double-stranded(dsRNA)-based RNA interference(RNAi)technology is a sustainable tool to effectively control insect pests.The dsRNA-based insecticides are known for their specificity,non-toxicity,and biodegradability.The current review introduces the dsRNA-based RNAi technique as a novel tool to control crop insect pests.The review highlights the mechanism behind dsRNA uptake into insect cells.Furthermore,it discusses the commercial aspects of different dsRNA-based products available in the market,their penetration rates,and public acceptance.The review details the latest developments in the field and the regulatory landscape regarding the technology.The advantages and limitations of dsRNA-based insecticides are discussed,and future research directions to overcome the potential challenges have been briefly suggested.The dsRNA-based insecticidal products may be a better alternative to conventional insecticides,thus delineating the resistance among insects and increasing agricultural productivity.

关 键 词：DSRNA INSECTICIDE integrated pest management RNA interference sustainable agriculture 

分 类 号：Q94[生物学—植物学]