高龄育龄妇女的生育困境与应用辅助生殖技术的现状与进展  

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作　　者：黄颂瑜 刘玉东[1] 王哲[1] 陈士岭[1] HUANG Song-yu;LIU Yu-dong;WANG Zhe

机构地区：[1]南方医科大学南方医院妇产科生殖医学中心,广州市510515

出　　处：《妇产与遗传（电子版）》2024年第1期27-32,共6页Obstetrics-Gynecology and Genetics (Electronic Edition)

基　　金：广州市2023年度基础与应用基础研究项目(2023A04J2291)。

摘　　要：目前有生育需求的高龄育龄妇女逐渐增多,大量研究表明女性生育力随年龄增加而下降。高龄导致女性卵子数量减少、卵子质量下降、子宫内膜功能损害、产科并发症增加,此部分女性需寻求辅助生殖技术,包括体外受精-胚胎移植、胚胎植入前遗传学检测及使用捐赠卵子等来获得后代。本文将从高龄育龄妇女面临的生育困境及其辅助生殖技术应用的现状与进展等方面进行综述。The desire to conceive among advanced maternal age women are on the rise,with extensive research indicating that female fertility declines with age.Advanced maternal age is associated with several reproductive challenges:decreased quantity and quality of oocytes,damage to the endometrial function,and an increased risk of obstetric complications.These challenges necessitate the use of assisted reproductive technologies(ART),such as in vitro fertilization‐embryo transfer(IVF‐ET),preimplantation genetic testing(PGT),and the utilization of donor oocytes.This article reviews the fertility dilemma encountered by these women and discusses the current status and advancements in ART.

关 键 词：高龄育龄妇女 辅助生殖技术 胚胎植入前遗传学检测 赠卵 生育力保存 

分 类 号：R715.5[医药卫生—妇产科学]