生姜中6-姜酚和芦丁对线虫抗衰老活性评价  

Evaluation of Anti-aging Activity of 6-gingerol and Rutin in Ginger Against Nematodes

作　　者：张凯恒 张淑华[1] 葛淑敏[1] ZHANG Kaiheng;ZHANG Shuhua;GE Shumin(School of Life Science and Technology,Changchun University of Science and Technology,Changchun 130022)

机构地区：[1]长春理工大学生命科学技术学院,长春130022

出　　处：《长春理工大学学报（自然科学版）》2024年第6期89-98,共10页Journal of Changchun University of Science and Technology(Natural Science Edition)

基　　金：吉林省科技厅科技发展计划项目(20220204127YY)。

摘　　要：生姜中的6-姜酚和芦丁是一种具有抗氧化和抗炎作用的活性成分。实验利用秀丽隐杆线虫(C.elegans)作为生物模型研究了6-姜酚与芦丁联合作用下对其寿命和抗氧化应激方面的作用。在一般条件下6-姜酚和芦丁都可以延长线虫的寿命且不会对线虫的繁殖产生影响,两者对于线虫的运动性、脂肪堆积和细胞凋亡都有明显的改善。此外,6-姜酚和芦丁还可以显著地降低活性氧(ROS),从而延长了线虫在极端反应下的存活时间。这些结果表明,6-姜酚作为生姜中主要的抗氧化物质,其和芦丁的联合作用在维持动物的健康和预防相关疾病方面值得进一步探索。6-gingerol and rutin found in ginger are active ingredients with antioxidant and anti-inflammatory properties.In this experiment,C.elegans was employed as a biological model to investigate the combined effects of 6-gingerol and rutin on lifespan and oxidative stress resistance.Under standard conditions,both 6-gingerol and rutin extend the lifespan of the nematodes without impacting their reproduction,and they significantly ameliorate the nematodes'motility,fat accumulation,and cell apoptosis.Additionally,6-gingerol and rutin markedly decrease reactive oxygen species(ROS),thereby enhancing the nematodes'survival under extreme conditions.These findings indicate that 6-gingerol,as the primary antioxidant in ginger,and its synergistic interaction with rutin warrant further exploration in maintaining animal health and preventing related diseases.

关 键 词：生姜 6-姜酚 芦丁 抗氧化 联合作用 秀丽隐杆线虫 

分 类 号：TS225.1[轻工技术与工程—粮食、油脂及植物蛋白工程]