基于重复测量方差分析LPE加半全血治疗感染指标CRP、PCT治疗效果分析  

Analysis of Therapeutic Effects of LPE Combined with Half-Whole Blood on Infection Indicators CRP and PCT Based on Repeated Measures ANOVA

作　　者：卢征翠 吴昌松[1] LU Zheng-cui;WU Chang-song(The First Affiliated Hospital of Qiannan Medical College for Nationalities,Duyun,558000,Guizhou)

机构地区：[1]黔南民族医学高等专科学校附属第一医院,贵州都匀558000

出　　处：《黔南民族医专学报》2024年第4期391-394,共4页Journal of Qiannan Medical College for Nationalities

摘　　要：目的:采用重复测量方差分析探讨LPE加半全血置换术治疗严重感染感染指标CRP、PCT的临床治疗效果。方法:收集20例严重感染,抗生素治疗48~72 h无效符合标准的患者,观察组(n=10)行LPE加半全血置换术治疗,对照组(n=10)行常规抗生素抗感染治疗。对两组治疗前后感染评价观察指标组间、组内比较,评价治疗效果。结果:观察组的感染评价指标治疗前后组内差异显著(P<0.05),对照组的感染评价指标治疗前后组内差异无统计学意义(P>0.05),治疗后两组的感染评价指标组间进行比较具有显著差异(P<0.05);两组患者CRP、PCT的时间效应、组间效应和交互效应有显著差异(P<0.01);两组感染指标的估计边缘平均数比较,观察组行LPE加半全血治疗感染指标CRP、PCT下降优于对照组常规抗生素治疗。结论:LPE加半全血治疗严重感染方案优于抗生素抗感染的常规治疗方案。Objective:To investigate the clinical efficacy of LPE plus hemofiltration in the treatment of severe infections using repeated measures analysis of variance(ANOVA)to assess the clinical efficacy of CRP and PCT.Methods:20 patients with severe infections who did not respond to antibiotic treatment for 48-72 hours and met the criteria were collected.The observation group(n=10)underwent LPE plus semi-whole blood replacement therapy,while the control group(n=10)received conventional antibiotic therapy for anti-infection.The evaluation of infection in both groups before and after treatment was compared between and within groups to assess the therapeutic effect.Results:The difference in the infection evaluation indicators between the observation group before and after treatment was significant(P<0.05),while there was no significant difference in the infection evaluation indicators between the control group before and after treatment(P>0.05).After treatment,there was a significant difference in the infection evaluation indicators between the two groups(P<0.05);There were significant differences in the time effect,group effect,and interaction effect of CRP and PCT between the two groups(P<0.01);The estimated marginal means of infection indicators in the two groups were compared,and the observation group showed a better reduction in infection indicators CRP and PCT after LPE plus half-blood treatment than the control group with conventional antibiotic treatment.Conclusion:The treatment regimen of LPE plus half-blood is superior to the conventional treatment regimen of antibiotic anti-infection for severe infections.

关 键 词：淋巴血浆置换术 C-反应蛋白 降钙素原 感染指标 

分 类 号：R457.1[医药卫生—治疗学]