二甲双胍、达格列净联合强化胰岛素治疗新诊断2型糖尿病的有效性和安全性研究  

Study on the Efficacy and Safety of Metformin,Dapagliflozin Combined with Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes Mellitus

作　　者：李文晴 LI Wen-qing(Juye County People's Hospital,Juye,274900,Shandong)

机构地区：[1]巨野县人民医院,山东巨野274900

出　　处：《黔南民族医专学报》2024年第4期404-407,共4页Journal of Qiannan Medical College for Nationalities

摘　　要：目的:明确二甲双胍、达格列净联合强化胰岛素治疗新诊断2型糖尿病的有效性和安全性。方法:随机将本院收治的新诊断2型糖尿病患者分为对照组(n=60,强化胰岛素治疗)和观察组(n=59,强化胰岛素联合二甲双胍、达格列净治疗),比较两组的血糖水平、胰岛素分泌指标、血脂水平与体质量指数、炎性因子与氧化应激指标及不良反应发生情况。结果:观察组的血糖水平显著优于对照组(P<0.05);观察组的胰岛素分泌指标改善情况均显著更佳(P<0.05);观察组的TC、LDL-C、TG及BMI值低于对照组,且HDL-C水平高于对照组(P<0.05);观察组的IL-17A、IL-23、MDA及SOD检测值均显著更优,相比对照组差异显著(P<0.05);观察组的不良反应发生率(5.85%)显著低于对照组的(36.67%)(P<0.05)。结论:对新诊断2型糖尿病患者采用二甲双胍、达格列净联合强化胰岛素治疗,能有效降低血糖水平,改善胰岛素分泌指标,减少不良反应,且安全性较高,值得推广。Objective:To evaluate the efficacy and safety of metformin,dapagliflozin combined with intensive insulin ther-apy in newly diagnosed type 2 diabetes mellitus.Methods:Newly diagnosed patients with type 2 diabetes mellitus admitted to our hospital were randomly divided into a control group(n=60,treated with intensive insulin therapy)and an observation group(n=59,treated with intensive insulin therapy combined with metformin and dapagliflozin).Blood glucose levels,insulin secretion indicators,blood lipid levels,body mass index(BMI),inflammatory factors,oxidative stress indicators,and adverse reactions were compared between the two groups.Results:The blood glucose levels in the observation group were significantly better than those in the control group(P<0.05).The improvement in insulin secretion indicators in the observation group was significantly better(P<0.05).The levels of TC,LDL-C,TG,and BMI in the observation group were lower than those in the control group,while the level of HDL-C was higher(P<0.05).The detection values of IL-17A,IL-23,MDA,and SOD in the observation group were significantly better,with significant differences compared to the control group(P<0.05).The incidence of adverse reactions in the observation group(5.85%)was significantly lower than that in the control group(36.67%)(P<0.05).Conclusion:Metformin,dapagliflozin combined with intensive insulin therapy in newly diagnosed patients with type 2 diabetes mellitus can effectively reduce blood glucose levels,improve insulin secretion indicators,reduce adverse reactions,and have high safety,which is worthy of promotion.

关 键 词：二甲双胍 达格列净 强化胰岛素 新诊断2型糖尿病 有效性 安全性 

分 类 号：R587.1[医药卫生—内分泌]