福建省赤腹松鼠源盖塔病毒的分子鉴定及其遗传进化分析  

Molecular identification and genetic evolution of Getah virus from red belly squirrels in Fujian Province

作　　者：鄢梓晴 粟硕[1] YAN Ziqing;SU Shuo(College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China)

机构地区：[1]南京农业大学动物医学院,江苏南京210095

出　　处：《畜牧与兽医》2025年第1期105-110,共6页Animal Husbandry & Veterinary Medicine

基　　金：国家重点研发计划项目(2022YFC2604203)。

摘　　要：盖塔病毒(Getah virus,GETV)是一种人畜共患的虫媒传播病毒,主要感染养殖动物,遗传多样性高,具有流行风险。本研究基于高通量测序技术,在来自福建省的死亡野生赤腹松鼠中首次发现了GETV,结合一代测序技术进一步鉴定到赤腹松鼠肺组织感染GETV,并成功获得该病毒的全基因组序列,命名为GETV/RS/China/2022毒株。基于GETV全基因组的系统发育分析结果表明,源自野生啮齿目动物的GETV/RS/China/2022毒株属于罕见GETV谱系Ⅱ型衍生株,这提示了GETV宿主谱的扩展以及野生动物对甲病毒进化和传播的重要性。Getah virus(GETV)is a zoonotic,insect-borne virus that mainly infects farmed animals and is of high genetic diversity and ep-idemic risk.In this study,GETV was first detected in dead wild red-bellies squirrels from Fujian Province.based on the high-throughput se-quencing technology.Combined with the next-generation sequencing technology,GETV infection in lung tissues of red-bellies squirrels was further identified,and the whole genome sequence of the virus was successfully obtained,named the GETV/RS/China/2022 strain.Phyloge-netic analysis based on the whole genome of GETV showed that the GETV/RS/China/2022 strain belonged to the rare GETV lineage typeⅡderivatives,which suggested the expansion of the GETV host spectrum and the importance of wild animals to the evolution and transmission of alphavirus.

关 键 词：啮齿目动物 盖塔病毒 甲病毒 系统发育分析 野生动物 

分 类 号：S852.65[农业科学—基础兽医学]