TRIM蛋白在宿主抗流感病毒感染中的作用  

Role of TRIM protein in host defence against influenza infection

作　　者：胡欣妍 高明阳 杨宣叶 王进千 吴玉湖 马晓霞[1] 张德荣[1] HU Xinyan;GAO Mingyang;YANG Xuanye;WANG Jinqian;WU Yuhu;MA Xiaoxia;ZHANG Derong(Biomedical Research Center,Northwest Minzu University/Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission/Gansu Tech Innovation Center of Animal Cell,Lanzhou 730030,China;College of Life Science and Engineering,Northwest Minzu University,Lanzhou 730010,China)

机构地区：[1]西北民族大学生物医学研究中心/生物工程与技术国家民委重点实验室/甘肃省动物细胞技术创新中心,甘肃兰州730030 [2]西北民族大学生命科学与工程学院,甘肃兰州730010

出　　处：《畜牧与兽医》2025年第1期138-146,共9页Animal Husbandry & Veterinary Medicine

基　　金：中央高校基本科研业务费专项资金资助(31920230063)。

摘　　要：泛素化是所有真核生物中蛋白质翻译后修饰(protein post-translational modifications,PTMs)之一,可调节数千种蛋白,其中,泛素-蛋白酶体系统(ubiquitin-proteasome system,UPS)可诱导蛋白酶体降解靶蛋白,随后激活多种信号通路,在多种细胞生命周期中发挥调节作用,并在细胞生命过程中的许多方面发挥至关重要的作用。三结构域蛋白(tripartite motif-containing proteins,TRIMs)是一类可以在胞内信号转导、细胞发育及凋亡、蛋白质质量控制、固有免疫反应、自噬、癌症中发挥重要调节作用的E3泛素连接酶。本文着重阐述了TRIMs在抗流感病毒感染中发挥的作用,包括对流感病毒蛋白的直接作用,对模式识别受体(pathogen recognition receptor,PRR)介导的固有免疫反应的调节以及对病毒自噬的诱导,为流感的防治提供更多新的思路,并为进一步深入研究TRIM家族成员介导的抗流感病毒感染机制奠定理论基础。Ubiquitination is one of the protein post-translational modifications(PTMs)found in all eukaryotes,regulating thousands of proteins.Among them,the ubiquitin-proteasome system(UPS)can induce the proteasome to degrade target proteins,and then activates a variety of signaling pathways,which plays a regulatory role in a variety of cell life cycles,and plays a crucial role in many aspects of cell life processes.Tripartite motif-containing proteins(TRIMs)are a class of E3 ubiquitin ligases that play an important role in the regulation of in-tracellular signal transduction,development,apoptosis,protein quality control,innate immune response,autophagy and cancer.In this re-view,we have focused on the role of TRIMs in anti-influenza virus infection,including the regulation of the innate immune response media-ted by the direct effect on influenza virus proteins,pathogen recognition receptor(PRR),and induction of viral autophagy.This provides more new ideas for the prevention and control of influenza virus,and further lays a theoretical foundation for in-depth research on the mecha-nism of anti-viral infection mediated by TRIM family members.

关 键 词：流感病毒 泛素化 抗病毒免疫 TRIM家族 

分 类 号：S852[农业科学—基础兽医学]