基于液相色谱-质谱联用技术的微生物药物代谢研究  

Research on Microbial Drug Metabolism Based on Liquid Chromatography-Mass Spectrometry

作　　者：曹小庆 魏理杨 杨琴 CAO Xiaoqing;WEI Liyang;YANG Qin(Nan’an Center for Disease Prevention and Control,Chongqing 401336,China)

机构地区：[1]重庆市南岸区疾病预防控制中心,重庆401336

出　　处：《工业微生物》2024年第6期1-3,共3页Industrial Microbiology

摘　　要：微生物可以通过独特的酶系统参与药物的转化,使药物活性增强或减弱,甚至可能产生毒性代谢物。液相色谱-质谱联用技术(LC-MS)凭借其高分辨率和灵敏度,可以精确测定药物及其代谢物的浓度,并提供微生物影响药物代谢的详细信息,进而支持药物的开发和安全评估。因此,文章将探讨基于液相色谱-质谱联用技术的微生物药物代谢,以期为现代医疗提供理论借鉴。Microorganisms participate in drug conversion through a unique enzyme system,which can lead to increased or decreased drug activities,and even produce toxic metabolites.Liquid chromatography-mass spectrometry(LC-MS)technology,based on its high resolution and sensitivity,can accurately determine the concentration of drugs and their metabolites,and provide detailed information about the impact of microorganisms on drug metabolism,thereby supporting the decision-making process of drug development and safety assessment.Therefore,this article will explore microbial drug metabolism based on liquid chromatography-mass spectrometry technology,in order to provide theoretical references for modern medicine.

关 键 词：液相色谱-质谱联用技术 微生物 药物代谢 

分 类 号：O657.63[理学—分析化学]