穿心莲内酯纳米脂质载体的制备及表征  

Preparation and Characterization of Andrographolide Nano-Lipid Carriers

作　　者：陈艳萍 黄冬怡 黄婷婷 廖伟菊 邓润芳 黄兴振[1] CHEN Yanping;HUANG Dongyi;HUANG Tingting;LIAO Weiju;DENG Runfang;HUANG Xingzhen(Pharmaceutical College,Guangxi Medical University,Nanning 536000,China;Pharmacy Department,People’s Hospital of Pingle County,Guilin 542400,China)

机构地区：[1]广西医科大学药学院,广西南宁536000 [2]平乐县人民医院药剂科,广西桂林542400

出　　处：《工业微生物》2024年第6期147-150,共4页Industrial Microbiology

摘　　要：应用新剂型制备技术可更深入地研究穿心莲内酯的药用价值。文章采用熔融乳化-超声-低温固化法制备穿心莲内酯纳米脂质载体,并优化工艺参数。结果表明,最佳条件为:单硬脂酸甘油酯和肉豆蔻酸异丙酯按1∶1比例复配,将吐温-80作为活性剂,药脂比值为1∶20,在75℃水浴下乳化60 min。该研究为开发穿心莲内酯提供了理论依据。The application value of andrographolide can be further developed by using the new preparation technique.In this study,andrographolide nano-lipid carriers were synthesized by using the melt-emulsification-ultrasonication-low temperature solidification method with process parameters improved.The ideal circumstances were a compound of glyceryl monostearate and isopropyl myristate,Tween-80 as a surfactant,a solid-to-liquid lipid ratio of 1∶1,The drug-lipid ratio was 1∶20 and emulsified for 60 min in a 75℃water bath.This study can provide a theoretical basis for further development of andrographolide.

关 键 词：穿心莲内酯 纳米脂质载体 表征 工艺优化 

分 类 号：R283.6[医药卫生—中药学]