辛开苦降法中药干预桥本甲状腺炎亚临床甲减的疗效观察  

Observation of Clinical Efficacy of Traditional Chinese Medicine Intervention under Thought of Acrid Dispersing and Bitter Descending on Subclinical Hypothyroidism of Hashimoto's Thyroiditis

作　　者：周静鑫[1] 缪娟[1] 金健[1] 杨杰[1] 鲁轶臻 龚燕冰 ZHOU Jing-xin;MIAO Juan;JIN Jian;YANG Jie;LU Yi-zhen;GONG Yan-bin(Affiliated Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 101121,China)

机构地区：[1]北京中医药大学东直门医院肾病内分泌科,北京101121

出　　处：《中华养生保健》2024年第24期1-4,共4页CHINESE HEALTH CARE

基　　金：北京市通州区科技计划项目(KJ2022CX046)。

摘　　要：目的临床观察应用辛开苦降法中药对桥本甲状腺炎亚临床甲减的干预疗效。方法将2023年1月—2024年1月就诊于东直门医院通州院区的桥本甲状腺炎亚临床甲减30例患者按随机数表法分为对照组与治疗组,每组15例。对照组予口服左甲状腺素钠片加用中药安慰剂,治疗组在对照组西药治疗基础上予辛开苦降法中药治疗,疗程为8周。结果与干预前比较,治疗组和对照组干预后均能有效降低促甲状腺激素(TSH)水平(P<0.05),且治疗组总有效率显著高于对照组(P<0.05)。两组干预后中医总症状积分均较干预前显著降低,且干预后治疗组中医总证侯积分有所改善,显著优于对照组(P<0.05)。结论辛开苦降法中药可以改善桥本甲状腺炎亚临床甲减患者的TSH水平,提高临床疗效。Objective To clinically observe and evaluate the intervention efficacy of Chinese herbal medicine under thought of acrid dispersing and bitter descending on subclinical hypothyroidism of Hashimoto's thyroiditis.Methods From January 2023 to January 2024,30 patients with subclinical hypothyroidism of Hashimoto's thyroiditis treated at Tongzhou Hospital,Dongzhimen Hospital,Beijing University of Chinese Medicine were randomly divided into control group and treatment group according to a random number table,with 15 cases in each group.The control group was given oral levothyroxine sodium tablets plus Chinese medicine placebo,and the treatment group was given Chinese herbal medicine treatment with Chinese medicine under thought of acrid dispersing and bitter descending on the basis of Western medicine treatment in the control group,with a course of 8 weeks.The changes in thyroid hormone levels and thyroid antibodies levels before and after intervention were compared between the two groups.Results Compared with before intervention,both the treatment group and the control group could effectively reduce the levels of thyroid stimulating hormone(TSH)after intervention(P<0.05),and the total effective rate of the treatment group was significantly higher than that of the control group(P<0.05).After the intervention,the TCM total symptom scores in both groups were significantly reduced compared to before the intervention,and the treatment group showed an improvement in the total symptom score after the intervention,which was significantly better than that of the control group(P<0.05).Conclusion Chinese herbal medicine under thought of acrid dispersing and bitter descending can improve the levels of TSH in subclinical hypothyroidism of Hashimoto's thyroiditis and enhance the clinical efficacy.

关 键 词：辛开苦降法 中药 桥本甲状腺炎 亚临床甲减 疗效观察 

分 类 号：R259[医药卫生—中西医结合]