增强型体外反搏联合中药治疗慢性心衰患者疗效影响的网状Meta分析  

Net Meta-analysis of Enhanced External Counterpulsation Combined with Traditional Chinese Medicine in the Treatment of Chronic Heart Failure

作　　者：傅婷婷 温志浩[2] FU Ting-ting;WEN Zhi-hao(Guangxi University of Chinese Medicine,Nanning Guangxi 532000,China;Department of Cardiology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Branch of National Clinical Research Center for Traditional Chinese Medicine Cardiovascular Diseases,Nanning Guangxi 530023,China)

机构地区：[1]广西中医药大学第一临床医学院,广西南宁532000 [2]广西中医药大学第一附属医院心内科,国家中医心血管病临床医学研究中心分中心,广西南宁530023

出　　处：《中华养生保健》2024年第24期9-14,共6页CHINESE HEALTH CARE

基　　金：国家自然科学基金地区基金(81660778);广西中医药适宜技术开发与推广项目(GZSY21-17)。

摘　　要：目的运用网状Meta分析方法,对增强型体外反搏技术联合中药治疗慢性心衰的临床疗效进行系统评价。方法在Pubmed、Cochrane Library、Web of Science、万方数据库、中国知网以及维普库中,筛选研究了2023年3月31日之前所发表的所有有关增强型体外反搏技术联合中药治疗慢性心衰的随机对照试验,所有数据处理均采用RevMan 5.3软件。结果最终纳入15项研究成果,共计1280例患者。数据结果显示:①在试验组中,左室射血分数(LVEF)表现更优(95%CI:3.72~9.47,P<0.001);②6 min步行试验(6MWT)结果也优于对照组(95%CI:27.62~65.99,P<0.001);③N端脑利钠肽前体(NT-proBNP)较对照组降低(95%CI:-353.25~-18.61,P=0.03);④心功能疗效优于对照组(95%CI:1.01~1.50,P=0.04);⑤中医证候疗效优于对照组(95%CI:1.05~1.38,P=0.009);⑥一氧化氮(NO)较对照组增高(95%CI:1.34~23.04,P=0.03);⑦临床疗效也优于对照组(95%CI:1.11~1.30,P<0.001)。结论在维持西医治疗的基础上,利用增强型体外反搏技术辅以中药治疗,能有助于改善慢性心力衰竭患者的LVEF、6MWT、心功能、中医证候、NO以及整体临床效果,同时能降低NT-proBNP的水平。Objective A systematic evaluation of the clinical efficacy of enhanced extracorporeal counterpulsation technique combined with traditional Chinese medicine in the treatment of chronic heart failure using reticulation meta-analysis.Methods A thorough search was conducted across PubMed,the Cochrane Library,Web of Science,Wanfang database,China Knowledge Network,and Wikipedia library.All Randomized Controlled Trials(RCTs)up to March 31,2023,examining the combined use of EECP technique and TCM in the treatment of chronic heart failure were scrutinized and studied.All data was processed using RevMan 5.3 software.Results Fifteen studies were ultimately included,encompassing a total of 1,265 patients.The outcomes showed that:①In the experimental group,Left Ventricular Ejection Fraction(LVEF)performed better(95%CI:3.72~9.47,P<0.001);②The results of the 6-minute walk test(6MWT)were also superior to the control group(95%CI:27.62~65.99,P<0.001);③N-terminal pro-Brain Natriuretic Peptide(NT-proBNP)was lower in the experimental group compared to the control group(95%CI:-353.25~-18.61,P=0.03);④Cardiac function was more efficacious than that of the control group(95%CI:1.01~1.50,P=0.04);⑤The efficacy of Traditional Chinese Medicine was superior to the control group(95%CI:1.05~1.38,P=0.009);⑥Nitric Oxide(NO)levels increased compared to the control group(95%CI:1.34~23.04,P=0.03);⑦Overall clinical efficacy was also superior to the control group(95%CI:1.11~1.30,P<0.001).Conclusion Adding EECP and TCM to a solely Western medical treatment regimen has shown improvements in LVEF,6MWT,cardiac function,the efficacy of TCM,NO levels,and overall clinical efficacy.It also effectively reduced the levels of NT-proBNP in patients with chronic heart failure.

关 键 词：体外反搏 中药 慢性心力衰竭 网状Meta分析 

分 类 号：R256.2[医药卫生—中医内科学]