ST2、IL-6、NT-proBNP水平与慢性阻塞性肺疾病严重程度的相关性分析  

Correlation Analysis of ST2,IL-6,NT-proBNP Levels with Severity of Chronic Obstructive Pulmonary Disease

作　　者：王涛[1] 朱华[1] 赵建平[1] Wang Tao;Zhu Hua;Zhao Jianping(Department of Clinical Laboratory,Taixing Second People's Hospital,Taizhou 225411,Jiangsu Province,China)

机构地区：[1]泰兴市第二人民医院检验科,江苏泰州225411

出　　处：《中外医药研究》2024年第34期18-20,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析慢性阻塞性肺疾病(COPD)患者血清中可溶性生长刺激表达基因2蛋白(ST2)、白细胞介素-6(IL-6)、N末端脑钠肽前体(NT-proBNP)水平与疾病严重程度的关系。方法:选取2022年1月—2023年12月泰兴市第二人民医院收治的103例COPD患者为研究对象,将40例急性加重期COPD(AECOPD)患者纳入AECOPD组,63例稳定期患者纳入稳定期组。根据肺功能将AECOPD组患者分为轻度组(13例)、中度组(19例)和重度组(8例)。检测患者血清ST2、IL-6、NT-proBNP水平,分析ST2、IL-6、NT-proBNP水平与病情严重程度的相关性。结果:AECOPD组ST2、IL-6、NT-proBNP水平高于稳定期组(P<0.001);中度组ST2、IL-6、NT-proBNP水平高于轻度组,重度组ST2、IL-6、NT-proBNP水平高于轻度组、中度组(P<0.05)。Pearson相关性分析显示,COPD患者ST2、IL-6、NT-proBNP水平与第1秒用力呼气容积、第1秒用力呼气容积/用力肺活量呈负相关(P<0.001)。结论:血清ST2、IL-6、NT-proBNP水平有助于评估COPD患者病情严重程度,可为COPD的临床诊断和治疗提供参考依据。Objective:To analyze the relationship between the serum levels of soluble growth stimulation gene 2 protein(ST2),interleukin-6(IL-6),N-terminal brain natriuretic peptide precursor(NT-proBNP)and disease severity in patients with chronic obstructive pulmonary disease(COPD).Methods:A total of one hundred and three COPD patients admitted to Taixing Second People's Hospital from January 2022 to December 2023 were selected as the study objects,forty patients with acute exacerbating COPD(AECOPD)were included in the AECOPD group,and sixty-three patients with stable stage were included in the stable group.According to lung function,AECOPD patients were divided into mild group(13 cases),moderate group(19 cases)and severe group(8 cases).The serum levels of ST2,IL-6 and NT-proBNP were detected,and the correlation between the levels of ST2,IL-6 and NT-proBNP and the severity of the disease was analyzed.Results:The levels of ST2,IL-6 and NT-proBNP in AECOPD group were higher than those in stable group(P<0.001);the level of ST2,IL-6 and NT-proBNP in moderate group was higher than that in mild group,and the level of ST2,IL-6 and NT-proBNP in severe group was higher than that in mild and moderate group(P<0.05).Pearson correlation analysis showed that the levels of ST2,IL-6 and NT-proBNP in COPD patients were negatively correlated with forced expiratory volume at the first second and forced expiratory volume at the first second/forced lung capacity(P<0.001).Conclusion:Serum ST2,IL-6,NT-proBNP levels are helpful to evaluate the severity of COPD patients,and can provide a reference for the clinical diagnosis and treatment of COPD.

关 键 词：慢性阻塞性肺疾病 可溶性生长刺激表达基因2蛋白 白细胞介素-6 N末端脑钠肽前体 

分 类 号：R563.9[医药卫生—呼吸系统]