冠状动脉严重狭窄的急性冠状动脉综合征患者经皮冠状动脉介入术后应用阿司匹林联合替格瑞洛的效果  

Effect of Aspirin Combined with Ticagrelor Antiplatelet therapy after Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome with Severe Coronary Artery Stenosis

作　　者：张晓荣 杨海洋 董春花 Zhang Xiaorong;Yang Haiyang;Dong Chunhua(Department of Cardiology,Jiayuguan Hospital of Traditional Chinese Medicine,Jiayuguan 735100,Gansu Province,China)

机构地区：[1]嘉峪关市中医医院心内科,甘肃嘉峪关735100

出　　处：《中外医药研究》2024年第34期36-38,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:观察冠状动脉严重狭窄的急性冠状动脉综合征(ACS)患者经皮冠状动脉介入术后应用阿司匹林联合替格瑞洛进行抗血小板治疗的效果。方法:选择2019年6月—2022年6月于嘉峪关市中医医院拟行冠状动脉介入术的冠状动脉严重狭窄的ACS患者80例为研究对象,按随机数字表法分为两组,各40例。两组术后均口服阿司匹林,在此基础上对照组口服氯吡格雷,观察组口服替格瑞洛。比较两组血小板计数、不良心血管事件发生情况、出血性事件发生情况。结果:术前及术后1年,两组血小板计数比较,差异无统计学意义(P>0.05);观察组不良心血管事件总发生率低于对照组(P=0.019);两组出血性事件总发生率比较,差异无统计学意义(P>0.05)。结论:冠状动脉严重狭窄的ACS患者经皮冠状动脉介入术后应用阿司匹林联合替格瑞洛进行抗血小板治疗的效果优于阿司匹林联合氯吡格雷,可降低不良心血管事件发生率,且不会影响血小板指标,不会增加出血性事件发生风险。Objective:To observe the effect of aspirin combined with ticagrelor antiplatelet therapy in patients with acute coronary syndrome(ACS)with severe coronary artery stenosis after percutaneous coronary intervention.Methods:A total of eighty ACS patients with severe coronary artery stenosis who were scheduled to undergo coronary intervention in Jiayuguan Hospital of Traditional Chinese Medicine from June 2019 to June 2022 were selected as the study objects,and were divided into two groups according to random number table method,with forty cases in each group.Both groups took aspirin orally after operation,clopidogrel was taken orally in control group and ticagrelor was taken orally in observation group.Platelet counts,adverse cardiovascular events and bleeding events were compared between the two groups.Results:There was no significant difference in platelet count between the two groups before and 1 year after surgery(P>0.05);the total incidence of adverse cardiovascular events in observation group was lower than that in control group(P=0.019);there was no significant difference in the total incidence of hemorrhagic events between the two groups(P>0.05).Conclusion:The effect of aspirin combined with ticagrelor antiplatelet therapy after percutaneous coronary intervention in ACS patients with severe coronary artery stenosis is better than that of aspirin combined with clopidogrel,which can reduce the incidence of adverse cardiovascular events without affecting platelet indexes and increasing the risk of hemorrhagic events.

关 键 词：急性冠状动脉综合征 冠状动脉严重狭窄 经皮冠状动脉介入术 抗血小板治疗 替格瑞洛 阿司匹林 氯吡格雷 

分 类 号：R541.4[医药卫生—心血管疾病]