双环醇联合替诺福韦治疗病毒性肝炎的效果观察  

Efficacy of Bicyclol Combined with Tenofovir in the Treatment of Viral Hepatitis

作　　者：张扶林 Zhang Fulin(First Department of Hepatology,Gansu Wuwei Cancer Hospital,Wuwei 733000,Gansu Province,China)

机构地区：[1]甘肃省武威肿瘤医院肝病一科,甘肃武威733000

出　　处：《中外医药研究》2024年第34期60-62,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:评估双环醇、替诺福韦联合治疗病毒性肝炎的临床效果。方法:选取2022年2月—2023年2月在甘肃省武威肿瘤医院肝病一科就诊的病毒性肝炎患者96例,通过随机数字表法分为联合组与对照组。对照组(n=48)予单一替诺福韦治疗,联合组(n=48)在对照组基础上加用双环醇治疗。对比两组疗效、肝功能指标、炎性指标,并观察不良反应。结果:联合组总有效率比对照组高(P=0.025)。治疗前,两组肝功能指标对比,无统计学差异(P>0.05);治疗后,两组肝功能指标水平降低,联合组低于对照组(P<0.05)。治疗前,两组炎性指标对比,无统计学差异(P>0.05);治疗后,两组炎性指标水平降低,联合组低于对照组(P<0.05)。两组不良反应总发生率对比,无统计学差异(P>0.05)。结论:联合使用双环醇、替诺福韦治疗病毒性肝炎作用确切,能够改善患者肝功能,抑制炎性反应,且未增加不良反应发生风险。Objective:To evaluate the clinical efficacy of bicyclol and tenofovir combination therapy for the treatment of viral hepatitis.Methods:From February 2022 to February 2023,96 patients with viral hepatitis who visited the First Department of Hepatology at Wuwei Cancer Hospital in Gansu Province were selected and divided into a combination group and a control group using a random number table method.The control group(n=48)received monotherapy with tenofovir,while the combination group(n=48)received additional bicyclol treatment.The efficacy,liver function indicators,and inflammatory indicators were compared between the two groups,and adverse reactions were observed.Results:The total effective rate in the combination group was higher than that in the control group(P=0.025).Before treatment,there was no statistical difference in liver function indicators between the two groups(P>0.05).After treatment,the levels of liver function indicators decreased in both groups,with the combination group showing lower levels than the control group(P<0.05).Similarly,before treatment,there was no statistical difference in inflammatory indicators between the two groups(P>0.05).After treatment,the levels of inflammatory indicators decreased in both groups,with the combination group again showing lower levels than the control group(P<0.05).There was no significant diffevernce in the total incidence of adverse reactions between two groups(P>0.05).Conclusion:The combined use of bicyclol and tenofovir has a definite effect in the treatment of viral hepatitis,capable of improving liver function,inhibiting inflammatory responses,and without increasing the risk of adverse reactions.

关 键 词：病毒性肝炎 替诺福韦 双环醇 

分 类 号：R512.6[医药卫生—内科学]