鸢尾素在动脉硬化性闭塞症中的作用机制  

Mechanism of irisin in arteriosclerosis obliterans

作　　者：曹逸凡 董夷宸 李永浩 白利康 李育杰 段红永[1] CAO Yifan;DONG Yichen;LI Yonghao;BAI Likang;LI Yujie;DUAN Hongyong(Department of Vascular Surgery,Shanxi Provincial People’s Hospital,Shanxi Medical University,Taiyuan 030001;Department of General Surgery,First Clinical School of Shanxi Medical University,Taiyuan 030012,China)

机构地区：[1]山西医科大学附属山西省人民医院血管外科,太原030001 [2]山西医科大学第一临床医学院普外科,太原030012

出　　处：《临床与病理杂志》2024年第8期1142-1149,共8页Journal of Clinical and Pathological Research

摘　　要：动脉硬化性闭塞症(arteriosclerosis obliterans,ASO)是一种主要影响大、中动脉的动脉粥样硬化性疾病,其发病率逐年上升,严重影响患者的生活质量,甚至可能导致截肢或死亡。鸢尾素作为一种运动诱导分泌的肽类物质,具有增加产热和调节代谢的功能,并通过多种机制缓解ASO的病理生理进程。其作用机制包括促进血管内皮细胞的增殖和修复,抑制氧化应激和慢性炎症反应,调节脂质代谢,改善血脂异常等。此外,鸢尾素在尼古丁诱导的血管损伤模型中表现出抗氧化作用,能减轻血管平滑肌细胞的表型转变以及动脉粥样硬化斑块的形成。这些多样化的机制展现了鸢尾素在改善ASO病理进程中的潜力。尽管目前的研究大多集中于基础层面,需进一步的临床验证以评估其在临床应用中的有效性和安全性,但这些发现为开发基于鸢尾素的干预措施提供了理论依据,为改善ASO患者的预后开辟了新的思路。Arteriosclerosis obliterans(ASO)is an atherosclerotic disease primarily affecting large and medium-sized arteries.Its incidence is increasing yearly,significantly impairing patients’quality of life and potentially leading to amputation or death.Irisin,a peptide induced by exercise,plays a role in thermogenesis and metabolic regulation,and it alleviates the pathophysiological processes of ASO through multiple mechanisms.These include promoting endothelial cell proliferation and repair,inhibiting oxidative stress and chronic inflammatory responses,regulating lipid metabolism,and improving dyslipidemia.Additionally,irisin exhibits antioxidant properties in nicotine-induced vascular injury models,mitigates the phenotypic transformation of vascular smooth muscle cells,and reduces atherosclerotic plaque formation.These diverse mechanisms highlight irisin’s potential in ameliorating the pathological procession of ASO.Although most current studies focus on basic research,further clinical validation is needed to assess its effectiveness and safety in clinical applications.Nonetheless,these findings provide a theoretical basis for developing irisin-based interventions,offering new insights for improving ASO patient outcomes.

关 键 词：鸢尾素 动脉硬化性闭塞症 机制 

分 类 号：R543.5[医药卫生—心血管疾病]