基于细胞捕获和释放的刺激响应型多功能核酸水凝胶  

Stimulus-Responsive Multifunctional Nucleic Acid Hydrogels Based on Cell Capture and Release

作　　者：王丹钰 郭梦珂 郭子涵 黄梦雨 易桦 张开翔 Danyu Wang;Mengke Guo;Zihan Guo;Mengyu Huang;Hua Yi;Kaixiang Zhang(School of Pharmacy,Zhengzhou University,Zhengzhou 450001,China;Henan Provincial Key Laboratory of Targeted Therapy and Diagnosis of Major Tumor Diseases,Zhengzhou 450001,China)

机构地区：[1]郑州大学药学院,郑州450001 [2]河南省肿瘤重大疾病靶向治疗与诊断重点实验室,郑州450001

出　　处：《化学进展》2024年第10期1567-1580,共14页Progress in Chemistry

基　　金：国家自然科学基金项目(No.22122409,22377110);河南省优势学科培育基金项目(No.222301420019)资助。

摘　　要：核酸水凝胶具有良好的亲水性、可调节性和生物相容性,在过去几年里引起了广泛的关注,特别是在医疗领域和智能材料领域展现了良好的应用前景。核酸水凝胶具有刺激响应型,例如pH、光、温度、化学触发等外部刺激均可以引起它的物理化学变化,实现对环境的感知和响应型形变,进行时空可控的精准细胞治疗。基于刺激响应型核酸水凝胶的细胞捕获与释放可用于控制和调节细胞的行为,在生物医学研究和应用中发挥重要作用。基于此,本文总结了纯核酸水凝胶以及聚合物-核酸杂化水凝胶的制备方法,探讨了不同刺激响应型核酸水凝胶的应用策略,并重点综述了其基于细胞捕获和释放在细胞成像、药物递送和细胞治疗等方面的研究。最后讨论了核酸水凝胶研究亟须解决的问题,并对核酸水凝胶的未来发展进行了展望。Nucleic acid hydrogels have good hydrophilicity,adjustability and biocompatibility,which have attracted considerable attention in the past few years,especially in the field of biomedicine and smart materials.Nucleic acid hydrogel is stimulus-responsive,meaning that external stimuli such as pH changes,light,temperature variations,and chemical triggers(including metal ion response,redox response,and enzyme response)can induce physical and chemical changes within them.Consequently,they are capable of perceiving their environment and undergoing responsive deformation,enabling precise cell therapy that can be controlled both temporally and spatially.Cell capture and release using stimulus-responsive nucleic acid hydrogels can control and modulate cellular behavior,and can also play an important role in biomedical research and applications,such as targeted drug therapies using the capture and release of specific cell types.Based on this,this paper summarizes the preparation methods of pure nucleic acid hydrogels and polymer-nucleic acid hybrid hydrogels,further discusses the application strategies of different stimuli-responsive nucleic acid hydrogels,and focuses on the research progress of cell capture and release in cell imaging,cell therapy and synergistic drug delivery.Finally,we discuss the urgent problems that need to be addressed in the research of nucleic acid hydrogels,and provide a prospect for their future development.

关 键 词：核酸水凝胶 刺激响应型 细胞捕获 细胞释放 生物医学 

分 类 号：O629.74[理学—有机化学]