高频超声观测超脉冲CO_(2)点阵激光穿透增生性瘢痕的实验研究  

Experimental study on high-frequency ultrasound observation of ultra-pulse CO_(2)fractional laser penetrating hypertrophic scars

作　　者：李程丽 夏晓辉[2] 欧阳华伟[1] Li Chengli;Xia Xiaohui;Ouyang Huawei(Department of Plastic&Laser Cosmetic,Hunan Provincial People′s Hospital(1st Affiliated Hospital of Hunan Normal University),Changsha 410005,China;Department of Ultrasound Imaging,Hunan Provincial People′s Hospital(1st Affiliated Hospital of Hunan Normal University),Changsha 410005,China)

机构地区：[1]湖南省人民医院(湖南师范大学附属第一医院)整形激光美容科,长沙410005 [2]湖南省人民医院(湖南师范大学附属第一医院)超声影像科,长沙410005

出　　处：《中国医师杂志》2024年第12期1841-1845,共5页Journal of Chinese Physician

基　　金：湖南省教育厅科学研究项目(22C0011)。

摘　　要：目的评估高频超声测量超脉冲CO_(2)点阵激光穿透增生性瘢痕深度的准确性和可靠性。方法收集2022年2月至2023年2月在湖南省人民医院行手术切除的人增生性瘢痕组织10例,用不同能量超脉冲CO_(2)点阵激光照射增生性瘢痕组织后,用高频超声观察并识别瘢痕中的激光气化孔道、组织变性区。将同一瘢痕组织进行病理切片、HE染色后采集瘢痕中激光气化孔道、组织变性区的图像,对比分析高频超声和病理组织切片两种结果的相关性和一致性。结果病理切片测量激光孔道深度的结果与高频超声测量激光孔道深度、组织变性区深度结果均存在强正相关(r=0.976、0.927,均P<0.001),其中病理切片与高频超声测量激光孔道深度的结果具有高度的一致性,在临床工作中可以互相替换使用。结论高频超声可用于评估超脉冲CO_(2)点阵激光照射增生性瘢痕后的瘢痕内部情况变化,并测量激光对瘢痕组织的穿透深度,测量结果具有较高的准确性和可靠性。ObjectiveTo evaluate the accuracy and reliability of high frequency ultrasound in measuring the penetration depth of hypertrophic scar with ultra-pulse CO_(2) fractional laser.MethodsFrom February 2022 to February 2023,10 cases of hypertrophic scar tissue underwent surgical resection in the Hunan Provincial People′s Hospital were collected.After irradiating the hypertrophic scar tissue with different energy ultra-pulse CO_(2) dot matrix laser,high-frequency ultrasound was used to observe and identify the laser gasification holes and tissue degeneration areas in the scar.The same scar tissue was histopathically sliced and the images of laser vaporized pores and tissue degeneration area were collected after hematoxylin-eosin(HE)staining,and the correlation and consistency of the two results of high-frequency ultrasound and pathological tissue section were compared and analyzed.ResultsThere was a strong positive correlation between the results of laser channel depth measured by pathological section and the results of laser channel depth measured by high-frequency ultrasound and the depth of tissue degeneration area(r=0.976,0.927,all P<0.001).Among them,the results of pathological section and high-frequency ultrasound measured laser channel depth were highly consistent,and could be used interchangeably in clinical work.ConclusionsHigh-frequency ultrasound can be used to evaluate the change of scar internal condition after ultra-pulsed CO_(2) dot matrix laser irradiation,and measure the penetration depth of laser on scar tissue.The measurement results have high accuracy and reliability.

关 键 词：激光 二氧化碳 高频超声 增生性瘢痕 

分 类 号：R622[医药卫生—整形外科]