CT增强检查造影剂急性不良反应的表现及危险因素分析  

Manifestations and Risk Factors of Acute Adverse Reactions to Contrast Agents in CT Enhanced Examination

作　　者：傅艳 陈长清 甘新春 FU Yan;CHEN Changqing;GAN Xinchun(Radiology Department,Yichun People's Hospital,Yichun 336000,China;不详)

机构地区：[1]宜春市人民医院放射科,江西宜春336000 [2]宜春市人民医院呼吸科,江西宜春336000

出　　处：《中国医学创新》2025年第1期144-149,共6页Medical Innovation of China

摘　　要：目的:分析CT增强检查造影剂急性不良反应的表现及危险因素。方法:回顾性收集2022年1月—2024年1月于宜春市人民医院接受CT增强检查的10017例患者的临床资料,筛查造影剂引发的急性不良反应的发生率和临床表现,将出现急性不良反应的患者纳入研究组(n=31),根据logistic回归分析应用条件,按照1∶2的比例选取62例未出现急性不良反应患者作为对照组。采用单因素分析和logistic回归分析CT增强检查造影剂急性不良反应发生的独立危险因素。结果:在10017例患者中,31例出现造影剂急性不良反应,急性不良反应发生率为0.31%(31/10017),主要临床表现为皮肤丘疹或瘙痒,大多数为轻度,多发生于注射完成后5 min内。研究组年龄≥60岁、造影剂种类为碘佛醇、有其他药物过敏史、造影剂注射流速≥4.5 mL/s患者占比均高于对照组,差异均有统计学意义(P<0.05)。检查前,研究组血肌酐水平较对照组高,差异有统计学意义(P<0.05)。logistic回归分析显示,年龄、造影剂种类、其他药物过敏史及造影剂注射流速为CT增强检查患者出现急性不良反应的独立危险因素(P<0.05)。结论:CT增强检查造影剂急性不良反应的发生风险较低,常见临床表现以轻度皮肤症状为主,临床上通过不同年龄或有无药物过敏史等为患者选择造影剂种类,通过控制造影剂注射流速,或可有效降CT增强检查造影剂急性不良反应的发生风险。Objective:To analyze the manifestations and risk factors of acute adverse reactions of contrast agents for CT enhanced examination.Method:Clinical data of 10,017 patients who received CT enhanced examination in Yichun People's Hospital from January 2022 to January 2024 were retrospectively collected,to screen the incidence and clinical manifestations of acute adverse reactions induced by contrast agents;patients with acute adverse reactions were included in the study group(n=31).According to the application conditions of logistic regression analysis,62 patients with no acute adverse reactions were selected as the control group according to the ratio of 1∶2.Using univariate analysis and logistic regression analysis to identify independent risk factors for acute adverse reactions to contrast agents in CT enhanced examinations.Result:Among the 10,017 patients,31 cases had acute adverse reactions with contrast agent,and the incidence of acute adverse reactions was 0.31%(31/10017).The main clinical manifestations were skin papules or pruritus,most of which were mild and mostly occurred within 5 minutes after injection.The proportion of patients aged≥60 years,the type of contrast agent was Ioversol,had allergic history of other drugs,and the injection flow rate of contrast agent≥4.5 mL/s in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).Before examination,the serum creatinine level of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).logistic regression analysis showed that age,type of contrast agents,history of allergy to other drugs and flow rate of contrast agent injection were independent risk factors for contrast agents acute adverse reactions in patients with CT enhanced examination(P<0.05).Conclusion:The risk of acute adverse reactions of contrast agents for CT enhanced examination is low,and the common clinical manifestations are mainly mild skin symptoms.Clinically,contrast age

关 键 词：CT 增强检查 造影剂 急性不良反应 风险因素 

分 类 号：R816[医药卫生—放射医学]