黄体酮联合低分子肝素钠治疗ART妊娠后复发性流产的疗效及对血清NLRP3、IL-1β、IL-18的影响  

Efficacy of progesterone combined with low molecular heparin sodium in the treatment of recurrent abortion after assisted reproductive technology pregnancy and its effect on serum NOD-like receptor protein 3,interleukin-1βand interleukin-18

作　　者：周娟 马媛 康卫卫 ZHOU Juan;MA Yuan;KANG Weiwei(Department of Obstetrics and Gynecology Reproductive Center,the Second Affiliated Hospital of Air Force Medical University(Tangdu Hospital)Xi′an 710038,Shaanxi,China)

机构地区：[1]空军军医大学第二附属医院(唐都医院)妇产科生殖中心,西安710038

出　　处：《中国性科学》2024年第12期54-58,共5页Chinese Journal of Human Sexuality

基　　金：国家自然科学基金助推项目(2021ZTXM-014)。

摘　　要：目的探讨黄体酮联合低分子肝素钠治疗辅助生殖技术(ART)妊娠后复发性流产的疗效及对血清NOD样受体蛋白3(NLRP3)、白介素(IL)-1β、IL-18的影响。方法选取2021年1月至2023年1月空军军医大学第二附属医院(唐都医院)收治的150例ART妊娠后复发性流产患者作为研究对象,根据抽签法分为观察组和对照组,每组75例。对照组采用黄体酮治疗,观察组采用黄体酮联合低分子肝素钠治疗。比较两组临床疗效及治疗前后血清NLRP3、IL-1β、IL-18、凝血功能指标、激素指标水平。结果观察组治疗总有效率高于对照组(P<0.05)。治疗后,两组血清NLRP3、IL-1β、IL-18、D-二聚体(D-D)、纤维蛋白降解产物(FDP)、纤维蛋白原(FIB)水平均降低,且观察组均低于对照组(P<0.05)。治疗后,两组孕酮(P)、雌二醇(E_(2))、人绒毛膜促性腺激素(hCG)水平均升高,且观察组均高于对照组(P<0.05)。结论黄体酮联合低分子肝素钠治疗ART妊娠后复发性流产患者疗效显著,能够降低患者炎症反应,改善患者激素水平和凝血功能。Objective To study the efficacy of progesterone combined with low molecular heparin sodium in the treatment of recurrent abortion after assisted reproductive technology(ART)pregnancy and its influence on serum NOD-like receptor protein 3(NLRP3),interleukin(IL)-1βand IL-18.Methods A total of 150 patients with recurrent abortion after ART pregnancy who were admitted to the Second Affiliated Hospital of Air Force Medical University(Tangdu Hospital)from January 2021 to January 2023 were chosen as study objects.They were split into observation group and control group using the lottery method,each consisting of 75 cases.Progesterone was administered to the control group,while progesterone combined low molecular heparin sodium were administered to the observation group.The two groups were compared in terms of the clinical efficacy,serum NLRP3,IL-1β,IL-18,coagulation function indexes,and hormone index levels prior to and after treatment.Results The overall treatment effectiveness rate of the observation group was higher than that of the control group(P<0.05).After treatment,the levels of serum NLRP3,IL-1β,IL-18,D-dimer(D-D),fibrin degradation product(FDP),and fibrinogen(FIB)in both group all decreased and those in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of progesterone(P),estradiol(E_(2)),and human chorionic gonadotropin(hCG)in the two groups all increased and those in the observation group were higher than those in the control group(P<0.05).Conclusions Progesterone combined with low molecular weight heparin sodium have significant efficacy in the treatment of patients with recurrent abortion after ART pregnancy.It can reduce the inflammatory reaction,improve the hormone levels and coagulation function of the patients.

关 键 词：黄体酮 低分子肝素钠 辅助生殖技术 妊娠 复发性流产 

分 类 号：R711[医药卫生—妇产科学]