精液TEX101、ECM1、ACRV1联合检测对男性不育的诊断价值  

Diagnostic value of combined detection of TEX101,ECM1 and ACRV1 in semen for male infertility

作　　者：李志勇 海玉姣 刘志华 孔二艳 海静 赵慧玲 Li Zhiyong;Hai Yujiao;Liu Zhihua;Kong Eryan;Hai Jing;Zhao Huiling(Department of Reproductive Medicine,Xinxiang Central Hospital,the Fourth Clinical College of Xinxiang Medical University,Xinxiang 453000,China)

机构地区：[1]河南省新乡市中心医院新乡医学院第四临床学院生殖医学科,453000

出　　处：《临床医学》2024年第12期71-73,共3页Clinical Medicine

基　　金：河南省医学科技攻关计划项目(LHGJ20210899)。

摘　　要：目的探讨精液中睾丸表达蛋白101(TEX101)、细胞外基质蛋白1(ECM1)、精子顶体小泡蛋白-1(ACRV1)联合检测对男性不育的诊断价值。方法选择2022年6月至2023年12月新乡市中心医院收治的98例男性不育患者为研究组,另选同期98例健康男性志愿者为对照组。检测两组受试人员精液中TEX101、ECM1、ACRV1水平。采用受试者工作特征曲线的AUC分析精液中TEX101、ECM1、ACRV1水平对男性不育的诊断价值。结果两组TEX101、ECM1、ACRV1水平比较,差异有统计学意义(P<0.05)。TEX101、ECM1、ACRV1单独诊断男性不育的灵敏度为95%、94%、94%,特异度为96%、97%、97%,联合诊断的灵敏度为97.96%,特异度为93.88%,准确度为95.92%。结论精液中TEX101、ECM1、ACRV1的表达量检测可作为男性不育的潜在标志。Objective To investigate the diagnostic value of testicular expression protein 101(TEX101),extracellular matrix protein 1(ECM1)and acrosomal vesicular protein-1(ACRV1)in semen in male infertility.Methods A total of 98 male infertility patients admitted to Xinxiang Central Hospital from June 2022 to December 2023 were selected as the study group,and 98 healthy volunteers from the same period were selected as the control group.The levels of TEX101,ECM1 and ACRV1 in semen of the two groups were detected.The diagnostic value of TEX101,ECM1 and ACRV1 levels in semen in male infertility was analyzed by AUC of subject working characteristic curve.Results There were significant differences in the levels of TEX101,ECM1 and ACRV1 between the two groups(P<0.05).The sensitivity of TEX101,ECM1 and ACRV1 for single diagnosis of male infertility was 95%,94%,94%,and the specificity was 96%,97%,97%;the sensitivity of combined diagnosis was 97.96%,the specificity was 93.88%,and the accuracy was 95.92%.Conclusions TEX101,ECM1 and ACRV1 expression in semen can be used as a potential marker of male infertility.

关 键 词：精液 睾丸表达蛋白101 细胞外基质蛋白1 精子顶体小泡蛋白-1 男性不育 诊断 

分 类 号：R698.2[医药卫生—泌尿科学]