健心颗粒化裁对稳定性冠状动脉疾病患者预后结局的改善效果研究  

Research on the improvement effect of modified Jianxin granules on the prognosis of patients with stable coronary artery disease

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作  者:苏天生[1] 卢静[1] 肖章武 王志民[1] SU Tiansheng;LU Jing;XIAO Zhangwu;WANG Zhimin(Department of Emergency,the Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fujian,Fuzhou 350003,China)

机构地区:[1]福建中医药大学附属第二人民医院急诊科,福建福州350003

出  处:《中国医药科学》2024年第23期112-115,共4页China Medicine And Pharmacy

基  金:福建省自然科学基金项目(2021J01872);福建中医药大学校管课题临床专项(XB2023021)。

摘  要:目的探讨健心颗粒化裁对稳定性冠状动脉疾病(SCAD)患者预后结局的改善效果。方法选取2022年1月至2023年1月福建中医药大学附属第二人民医院收治的SCAD患者100例为研究对象,采用随机数表法将其分为对照组(50例)和研究组(50例)。对照组实施常规西医治疗,研究组实施常规西医联合健心颗粒化裁治疗。比较两组治疗前后血液流变学指标、西雅图心绞痛量表(SAQ)评分,疗程结束后随访6个月的SAQ评分及复合心血管不良事件(MACE)发生率。结果治疗后,两组血浆黏度、红细胞聚集指数、血小板黏附率及血小板最大聚集率均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后及随访6个月后,两组SAQ各维度评分均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);随访6个月后,研究组MACE发生率为4.00%,明显低于对照组的16.00%,差异有统计学意义(P<0.05)。结论健心颗粒化裁治疗可改善SCAD患者血液流变学及心绞痛症状,降低MACE发生率,改善患者预后。Objective To explore the improvement effect of modified Jianxin granules on the prognosis of patients with stable coronary artery disease(SCAD).Methods A total of 100 patients with SCAD admitted to and treated in the Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2022 to January 2023 were selected,and they were divided into the control group(n=50)and the study group(n=50)according to the random number table method.The control group was treated with conventional western medicine,while the study group was treated with conventional western medicine combined with modified Jianxin granules.The hemorheological indices and Seattle angina questionnaiire(SAQ)scores before and after treatment,and follow up of 6 months after the treatment in SAQ and major adverse cardiac events(MACE)were compared between the two groups.Results After treatment,the maximum platelet aggregation rate,platelet adhesion rate,plasma viscosity and erythrocyte aggregation index of the two groups were all lower than those before treatment,and those in the study group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment and 6 months of follow-up,the scores of SAQ in both groups were higher than those before treatment,and those in the study group were higher than those in the control group,with statistically significant differences(P<0.05).After 6 months of follow-up,the incidence of MACE in the study group was 4.00%,obviously lower than 16.00%in the control group,with statistically significant difference(P<0.05).Conclusion Modified Jianxin granules treatment can improve the hemorheology and angina symptoms of SCAD patients,also reduce the incidence of MACE and improve the prognosis of patients.

关 键 词:健心颗粒化裁 稳定性冠状动脉疾病 血液流变学 心绞痛 心血管不良事件 

分 类 号:R259[医药卫生—中西医结合]

 

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